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NCT07424963: HEPCA
Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)
NA trial testing Hepatic venous pressure gradient measurement in Cirrhosis in 40 participants. Currently enrolling.
31 December 2027
Quick facts
| Lead sponsor | Military University Hospital, Prague |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 40 |
| Start date | 30 May 2025 |
| Primary completion | 31 December 2027 |
| Estimated completion | 31 December 2028 |
| Sites | 2 locations across Czechia |
Drugs / interventions tested
- Hepatic venous pressure gradient measurement
- Endoscopic ultrasound-guided portal pressure gradient measurement
Conditions studied
- Cirrhosis — all drugs for Cirrhosis →
- Portal Hypertension — all drugs for Portal Hypertension →
- EUS — all drugs for EUS →
- Non-Cirrhotic Portal Hypertension — all drugs for Non-Cirrhotic Portal Hypertension →
Sponsor
Military University Hospital, Prague
Who can join
Adults 18 to 75, any sex, with Cirrhosis or Portal Hypertension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this interventional trial is to compare in measuring of portal hypertension by HVPG and EUS-PPG in subject indicated to HVPG measurement. The primary question is whether EUS-PPG provides measurements really equivalent to HVPG in terms of gradient accuracy. Participants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07424963
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Military University Hospital, Prague trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07424963 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Military University Hospital, Prague
- Last refreshed: 20 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07424963.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing