Examining of the Acute Effects of Low-Level Laser Therapy (LLLT) on Pain Threshold and Tolerance: a Randomized Controlled Trial

NCT07422272 NA RECRUITING

Pain is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Low-Level Laser Therapy (LLLT) has gained attention as a safe, noninvasive intervention with analgesic and anti-inflammatory effects. This study examines whether a single session of LLLT can produce immediate changes in pain threshold and pain tolerance in healthy adults, compared to a sham laser control.

Details

Lead sponsor	European University of Lefke
Phase	NA
Status	RECRUITING
Enrolment	52
Start date	2025-12-15
Completion	2026-02

Conditions

• Pain Threshold
• Pain Tolerance
• Acute Pain
• Low-level Laser Therapy
• LLLT vs Sham

Interventions

• Low-Level Laser Therapy (LLLT)
• Sham LLLT

Primary outcomes

• Electrical Pain Threshold Intensity (mA) — Pre-intervention and immediately post-intervention
  Electrical pain threshold will be measured using tetanic faradic stimulation with gradual increases in current intensity. The cathode will be placed on the palmar surface of the third finger and the anode over the medial epicondyle. Participants will verbally indicate the point at which the electrical sensation is first perceived as painful. The stimulation intensity (in milliamperes) at this point will be recorded.
• Electrical Pain Tolerance Intensity (mA) — Pre-intervention and immediately post-intervention
  Electrical pain tolerance will be measured using tetanic faradic stimulation using the same electrode placement and stimulation parameters. Participants will verbally indicate the maximum level of pain they are willing to tolerate. The stimulation intensity (in milliamperes) at this point will be recorded.

Countries

Cyprus