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NCT07422181: PlaCEUS
PlaCEUS: Feasibility Study of Contrast-enhanced Ultrasound to Visualize Maternal Uterine Spiral Arteries Postpartum.
NA trial testing SonoVue (sulphur hexafluoride microbubbles) in Spiral Arteries in 5 participants. Currently enrolling.
1 June 2026
Quick facts
| Lead sponsor | Maxima Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 5 |
| Start date | 17 December 2025 |
| Primary completion | 1 June 2026 |
| Estimated completion | 1 July 2026 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- SonoVue (sulphur hexafluoride microbubbles) — full drug profile →
Conditions studied
- Spiral Arteries — all drugs for Spiral Arteries →
- Uterine Artery Hemodynamics — all drugs for Uterine Artery Hemodynamics →
- Contrast Enhanced Ultrasound — all drugs for Contrast Enhanced Ultrasound →
- Doppler Parameters — all drugs for Doppler Parameters →
Sponsor
Maxima Medical Center
Who can join
18 and older, female only, with Spiral Arteries or Uterine Artery Hemodynamics. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
During pregnancy, unique blood vessels form within the uterine wall, known as spiral arteries. These vessels originate from the uterine artery, which is the main artery supplying blood to the uterus. Throughout pregnancy, spiral arteries undergo significant changes to increase blood and oxygen flow to the placenta, ensuring the developing baby receives adequate nutrients. When these arteries fail to remodel properly, complications such as pre-eclampsia or fetal growth restriction can occur. Until now, direct observation and evaluation of spiral arteries during pregnancy has not been feasible. Contrast-enhanced ultrasound may provide a breakthrough in this area. In this study, the investigators aim to use this imaging technique to visualize spiral arteries after the placenta has been delivered. If successful, this could allow to assess their structural quality. Additionally, the investigators will employ ultrasound to monitor physiological changes in the uterine artery during late pregnancy (after 37 weeks), during labour, and postpartum. By conducting these measurements, the investigators hope to develop methods for detecting spiral artery abnormalities earlier in pregnancy. Early identification could enable timely interventions and help prevent severe complications.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07422181
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other Maxima Medical Center trials
Trials by the same sponsor.
- NCT07077109 — Feasibility Study: Continuous Fetal Monitoring During Maternal Exercise · NA · not yet recruiting
- NCT07061366 — The Use of the Bambi-Belt in Exteremly Preterm Infants: an Implementation Study. · recruiting
- NCT07152106 — Amniotic Fluid & the Preterm Gut · recruiting
- NCT06392178 — SugarVita: a Digital Board Game · NA · recruiting
- NCT06151613 — Continuous Non-invasive Electrophysiological Monitoring in High Risk Pregnancies · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07422181 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Maxima Medical Center
- Last refreshed: 19 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07422181.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing