Last reviewed · How we verify
NCT07419594: EstraMemo
Estradiol and Intrusive Memories
NA trial testing Estradiol Valerate in PTSD in 273 participants. Currently enrolling.
31 December 2027
Quick facts
| Lead sponsor | Charite University, Berlin, Germany |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 273 |
| Start date | 19 August 2024 |
| Primary completion | 31 December 2027 |
| Estimated completion | 29 February 2028 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Estradiol Valerate (ESTRADIOL VALERATE) — full drug profile →
- Placebo
Conditions studied
- PTSD — all drugs for PTSD →
- Intrusive Memories — all drugs for Intrusive Memories →
- Intrusion Symptom — all drugs for Intrusion Symptom →
- Trauma — all drugs for Trauma →
Sponsor
Charite University, Berlin, Germany
Who can join
Adults 18 to 45, female only, with PTSD or Intrusive Memories. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma. A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls. This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07419594
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07419594 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Charite University, Berlin, Germany
- Last refreshed: 19 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07419594.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing