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NCT07416721
Cooling of the Knee After Total Knee Arthroplasty
NA trial testing Cool Down Liquid with Bandage ( CoolDown, CH) in Osteoarthritis, Knee in 99 participants. Not yet recruiting.
1 November 2026
Quick facts
| Lead sponsor | Clinical Center of Vojvodina |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 99 |
| Start date | 1 March 2026 |
| Primary completion | 1 November 2026 |
| Estimated completion | 1 March 2027 |
Drugs / interventions tested
- Cool Down Liquid with Bandage ( CoolDown, CH)
- Ice package cooling system
- Standard Postoperative Protocol Without Cooling
Conditions studied
- Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
- Total Knee Replacement — all drugs for Total Knee Replacement →
Sponsor
Clinical Center of Vojvodina
Who can join
Eligibility, any sex, with Osteoarthritis, Knee or Total Knee Replacement. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study investigates whether cooling the knee after total knee replacement surgery can reduce pain and improve early recovery. After surgery, patients are randomly assigned to one of three groups: cooling with a liquid cooling bandage, cooling with an ice pack, or standard postoperative care without cooling. Cooling begins 24 hours after surgery and continues for two weeks. Pain levels, use of pain medication, blood values, knee swelling, knee movement, and length of hospital stay are recorded. The goal is to determine whether postoperative knee cooling provides additional benefits compared with standard care.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07416721
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Osteoarthritis, Knee
Currently open trials in the same condition.
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- NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
- NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
- NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
- NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting
Other Clinical Center of Vojvodina trials
Trials by the same sponsor.
- NCT07405840 — Application of Autologous Stem Cells From Adipose Tissue in the Regeneration of Knee Joint Cartilage · Phase 4 · active not recruiting
- NCT06030791 — BTB Graft Harvest and Donor Site Morbidity After ACL Reconstruction · unknown
- NCT06838585 — Intra-Abdominal Sepsis and Relationship Between Cumulative Fluid Balance and Serum Sodium and Chloride Levels and In-Hos · completed
- NCT05390294 — Survival With Patients Treated With Salivary Gland Cancer · completed
- NCT03825133 — The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Pla · Phase 4 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07416721 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Clinical Center of Vojvodina
- Last refreshed: 18 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07416721.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing