Last reviewed · How we verify
NCT07416318
Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics
trial in Saliva in 21 participants. Completed in 2 April 2025.
4 March 2025
Quick facts
| Lead sponsor | Kocaeli University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 21 |
| Start date | 25 December 2024 |
| Primary completion | 4 March 2025 |
| Estimated completion | 2 April 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Saliva — all drugs for Saliva →
- Oral Lichen Planus — all drugs for Oral Lichen Planus →
- Oral Leukoplakia — all drugs for Oral Leukoplakia →
- Proteomics — all drugs for Proteomics →
Sponsor
Kocaeli University
Who can join
Adults 29 to 71, any sex, with Saliva or Oral Lichen Planus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to compare salivary proteome profiles in patients with Oral Lichen Planus (OLP), Oral Leukoplakia (OL), and healthy individuals without oral mucosal disease. The main questions it aims to answer are: 1. Do salivary protein expression patterns differ between patients with OLP, OL, and healthy controls? 2. Can specific differentially expressed proteins serve as potential biomarkers for distinguishing OLP and OL from each other and from healthy individuals? Researchers will compare salivary proteomic profiles from patients with OLP, patients with OL, and healthy controls to determine whether measurable differences in protein expression exist between the groups. Participants will: 1. Provide unstimulated saliva samples collected as part of the study protocol. 2. Undergo grouping based on clinical diagnosis (OLP, OL, or healthy control), after which samples will be pooled and analyzed using nano-liquid chromatography coupled with tandem mass spectrometry (nLC-MS/MS) and label-free protein quantification methods.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07416318
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Saliva
Currently open trials in the same condition.
- NCT07293481 — Discovery and Validation of Periodontitis Biomarkers · recruiting
- NCT06924372 — Application of Salivary Biomarkers in Risk Assessment for Oral Diseases in Children With Type 1 Diabetes · active not recruiting
- NCT06276335 — Influence of Timing of Implant Placement on Early Healing Molecular Events · NA · recruiting
- NCT06354205 — Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels · NA · recruiting
Other Kocaeli University trials
Trials by the same sponsor.
- NCT06737887 — The Effect of Preoperative Stoma Simulation on Anxiety and Postoperative Adaptation · NA · recruiting
- NCT07483593 — Baseline Gastric Volume in Diabetic vs Non-Diabetic Patients · not yet recruiting
- NCT07536659 — Evaluation of Serum Autophagic Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Individuals · enrolling by invitation
- NCT07482696 — Electromyographic Biofeedback Therapy in Patients With Dyssynergic Defecation · NA · not yet recruiting
- NCT07497945 — Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07416318 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kocaeli University
- Last refreshed: 18 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07416318.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing