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NCT07414446: SONAS
Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device
NA trial testing Transcranial Ultrasound Device in Hereditary Haemorrhagic Telangiectasia in 40 participants. Currently enrolling.
1 April 2026
Quick facts
| Lead sponsor | St. Antonius Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 40 |
| Start date | 7 January 2026 |
| Primary completion | 1 April 2026 |
| Estimated completion | 1 April 2026 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Transcranial Ultrasound Device
Conditions studied
- Hereditary Haemorrhagic Telangiectasia — all drugs for Hereditary Haemorrhagic Telangiectasia →
- PFO - Patent Foramen Ovale — all drugs for PFO - Patent Foramen Ovale →
- Pulmonary Arteriovenous Malformation — all drugs for Pulmonary Arteriovenous Malformation →
Sponsor
St. Antonius Hospital
Who can join
18 and older, any sex, with Hereditary Haemorrhagic Telangiectasia or PFO - Patent Foramen Ovale. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to learn how well the SONAS ultrasound device can detect right-to-left shunts of adults with hereditary hemorrhagic telangiectasia (HHT) who are already scheduled for a contrast bubble echocardiogram (TTCE). The main questions it aims to answer are: 1. How accurately does SONAS detect right-to-left shunts compared to the standard TTCE test? 2. Can SONAS results help tell the difference between shunts in the heart and shunts in the lungs? Participants will wear a headband with the SONAS device on the head while they undergo their routine TTCE bubble test. They will receive the usual contrast (agitated saline) through a vein, and both SONAS and TTCE signals will be recorded at the same time. There will be one examination in rest, and one during a breathing exercise (the Valsalva manoeuvre).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07414446
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Hereditary Haemorrhagic Telangiectasia
Currently open trials in the same condition.
- NCT07111598 — Immunological Effects of Iron Supplementation in HHT Disease · NA · recruiting
- NCT03841422 — Evaluation of Video-assisted Instructions of Nasal Self-packing in Patients with HHT · active not recruiting
Other St. Antonius Hospital trials
Trials by the same sponsor.
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- NCT07157358 — Online Medical Hypnosis Exercises to Improve Mental Health in Primary School Children and Prevent Future Mental Health I · NA · recruiting
- NCT06960174 — Virtual Renality: Assessing the Impact of Virtual Reality on Preoperative Planning in Renal Cancer Surgery · NA · not yet recruiting
- NCT06861387 — Cryo Nerve Block Trial · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07414446 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by St. Antonius Hospital
- Last refreshed: 17 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07414446.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing