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NCT07411118
RCT of EFTR Versus STER for GIST Treatment
NA trial testing Endoscopic full thickness resection (EFTR) / Exposed non-tunneling EFTR in Small Size Gastrointestinal Stromal Tumors in 136 participants. Currently enrolling.
1 December 2032
Quick facts
| Lead sponsor | Chinese University of Hong Kong |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 136 |
| Start date | 1 February 2025 |
| Primary completion | 1 December 2032 |
| Estimated completion | 1 February 2033 |
| Sites | 4 locations across China, Hong Kong, Japan, India |
Drugs / interventions tested
- Endoscopic full thickness resection (EFTR) / Exposed non-tunneling EFTR
- Submucosal Tunneling Endoscopic Resection (STER) / Exposed tunneling EFTR
Conditions studied
- Small Size Gastrointestinal Stromal Tumors — all drugs for Small Size Gastrointestinal Stromal Tumors →
- GIST — all drugs for GIST →
Sponsor
Chinese University of Hong Kong
Who can join
Adults 18 to 75, any sex, with Small Size Gastrointestinal Stromal Tumors or GIST. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Endoscopic resection has been increasing utilized as the treatment for small size gastrointestinal stromal tumors (GIST), of which the best resection method has not been identified. We aim to compare the outcomes of endoscopic full thickness resection (EFTR) versus submucosal tunnelling endoscopic resection (STER) for clinical small gastric GIST. We hypothesize that EFTR could achieve better complete margin negative resection than STER without increase in adverse event. This is an international multi-center double blinded randomized controlled trial involving four high volume centers from Hong Kong, mainland China, India and Japan. Adult patients with clinical 1.0-3.Scm gastric GIST undergoing endoscopic resection would be recruited. Patients would be randomized to undergo EFTR (intervention) or STER (Control) by expert endoscopists under general anaesthesia according to well published methods.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07411118
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07411118 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
- Last refreshed: 13 February 2026
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