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NCT07408765

Physical Activity, Fatigue, Social Support, and Psychological Well-Being in Women With Primary Hypothyroidism

Recruiting now Last updated 19 February 2026
What this trial tests

trial testing Women with primary hypothyroidism sample in Hypothyroidism Primary in 96 participants. Currently enrolling.

Timeline
16 February 2026
Primary endpoint
28 April 2026
15 May 2026

Quick facts

Lead sponsorUniversity of Oviedo
StatusRecruiting now
Study typeOBSERVATIONAL
Enrollment96
Start date16 February 2026
Primary completion28 April 2026
Estimated completion15 May 2026
Sites1 location across Spain

Drugs / interventions tested

Conditions studied

Sponsor

University of Oviedo

Who can join

18 and older, female only, with Hypothyroidism Primary. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background. Primary hypothyroidism, both clinical and subclinical, is frequently associated with persistent fatigue, reduced psychological well-being, and lower levels of physical activity in adult women. However, evidence integrating these psychosocial factors remains limited and methodologically heterogeneous. Objective. To analyze the association between physical activity and fatigue, social support, and psychological well-being in women with primary hypothyroidism; to compare these profiles between clinical and subclinical hypothyroidism; and to explore the moderating effect of social support and psychological well-being on the relationship between fatigue and physical activity. Methods. An observational, analytical, multicenter cohort study will be conducted including 96 adult women with primary hypothyroidism from the Principality of Asturias. Physical activity levels will be assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), while fatigue, social support, and psychological well-being will be measured using the Fatigue Severity Scale (FSS), the Medical Outcomes Study Social Support Survey (MOS-SSS), and the WHO-5 Well-Being Index, respectively. Confounding variables will include age, body mass index, type of hypothyroidism (clinical or subclinical), and time since diagnosis. Descriptive analyses, comparisons between clinical and subclinical groups, and multiple linear regression models will be performed. Expected results. The study is expected to identify physical activity levels within the sample and determine which psychosocial factors are independently associated with physical activity. Additionally, fatigue is anticipated to be negatively associated with physical activity, whereas social support and psychological well-being are expected to show positive associations and potential moderating effects.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

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