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NCT07405957
Effects of Two Different Lion's Mane Extracts (Lions Mane Fruiting Body & Lions Mane Fruiting Body With Mycellium) on Cognitive Performance, Subjective Affect, Serum Biomarkers, and Gut Microbiota in Healthy Adults
NA trial testing Lion Mane (Hericium erinaceus) fruiting body extract - Nordic Origin in Healthy Adult Females in 87 participants. Completed in 10 September 2025.
27 June 2025
Quick facts
| Lead sponsor | Applied Food Sciences Inc. |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 87 |
| Start date | 11 February 2025 |
| Primary completion | 27 June 2025 |
| Estimated completion | 10 September 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Lion Mane (Hericium erinaceus) fruiting body extract - Nordic Origin
- Lions Mane (Hericium erinaceus) Fruiting body and mycelium
- Maltodextrin (Placebo) — full drug profile →
Conditions studied
- Healthy Adult Females — all drugs for Healthy Adult Females →
- Healthy Adult Male — all drugs for Healthy Adult Male →
Sponsor
Applied Food Sciences Inc.
Who can join
Adults 40 to 65, any sex, with Healthy Adult Females or Healthy Adult Male. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A randomized, double-blind, placebo-controlled, parallel-arm study design, of healthy men and women assigned to one of three groups: 1 gram/day of MycothriveTM Nordic origin fruiting body lion's mane (M-LM), 1 gram/day of a commercially available mycelium and fruiting body lion's mane (MFB-LM), or placebo (PL) to evaluate Lions mane potential cognitive and gut health benefits in a controlled daily dose for 45 days.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07405957
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Healthy Adult Females
Currently open trials in the same condition.
- NCT07515417 — Effect of Magnesium Supplementation on Sleep Quality and Cognitive Function in Saudi Adults · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07405957 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Applied Food Sciences Inc.
- Last refreshed: 13 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07405957.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing