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NCT07405632: HECOG
The Impact of Supplementation With Hericium Erinaceus (Lion's Mane) Extract on Cognitive Functioning
NA trial testing Hericium erinaceus Supplementation in Attention in 85 participants. Completed in 11 October 2025.
11 October 2025
Quick facts
| Lead sponsor | University of Social Sciences and Humanities, Warsaw |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 85 |
| Start date | 13 January 2025 |
| Primary completion | 11 October 2025 |
| Estimated completion | 11 October 2025 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- Hericium erinaceus Supplementation
- Placebo
Conditions studied
- Attention — all drugs for Attention →
- Memory — all drugs for Memory →
- Cognitive Function and Well-Being — all drugs for Cognitive Function and Well-Being →
Sponsor
University of Social Sciences and Humanities, Warsaw
Who can join
Adults 30 to 50, female only, with Attention or Memory. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this study is to determine whether supplementation with Hericium erinaceus (Lion's Mane) extract enhances selected cognitive functions in healthy, actively working, middle-aged women. We aim to investigate a broad spectrum of cognitive functions to identify which, if any, are affected both immediately and after prolonged supplementation with Hericium erinaceus extract. Our main research questions are as follows: 1. Can Hericium erinaceus extract supplementation modify cognitive status? 2. Is there an immediate effect on cognition following a single intake of Hericium erinaceus extract? 3. Does prolonged supplementation with Hericium erinaceus extract influence cognitive functioning? 4. Which cognitive functions are affected, and will the patterns differ between immediate effects and those observed after long-term supplementation? 5. Will participants report subjective cognitive enhancement? Our main hypotheses are as follows: 1. A single dose of Hericium erinaceus extract will produce an acute effect, improving attention 45 minutes after intake. 2. An eight-week supplementation period with Hericium erinaceus extract will produce a chronic effect, improving long-term memory. 3. The investigators will compare Hericium erinaceus extract with a placebo (a visually identical substance that contains no active ingredients) to determine whether the extract effectively enhances cognitive functioning. Participants will: 1. Take a Hericium erinaceus extract or placebo capsule daily for 2 months. 2. Visit SWPS University for baseline assessments before beginning supplementation (T0), a follow-up assessment 45 minutes after the initial intake (T1), and additional assessments at 1 week (T2) and 2 months (T3). 3. Complete neuropsychological testing and questionnaires during the T1, T2, and T3 visits. 4. Maintain their usual dietary habits throughout the study.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07405632
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07405632 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Social Sciences and Humanities, Warsaw
- Last refreshed: 12 February 2026
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