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Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients: A Scalable and Sustainable Model (AMBU-VAX)
AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting. The study targets adult and elderly patients with chronic diseases or immunocompromising conditions who are eligible for vaccination according to national immunization guidelines. Vaccination is actively proposed during outpatient visits, hospital admissions, or at discharge and, when accepted, administered within the hospital or coordinated with local public health vaccination services. The study aims to evaluate the feasibility, uptake, and completion of hospital-based vaccination pathways and to support integration between hospital and territorial prevention services for vulnerable populations.
Details
| Lead sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
|---|---|
| Status | NOT_YET_RECRUITING |
| Enrolment | 1500 |
| Start date | 2026-02 |
| Completion | 2027-02 |
Conditions
- Chronic Disease
- Immunocompromised
- HIV Infection
- Chronic Kidney Disease
- Solid Organ Transplantation
- Hematopoietic Stem Cell Transplantation
- Cancer
- Autoimmune Diseases
- Inflammatory Bowel Disease
- Asplenia
Interventions
- Hospital-Based Vaccination Pathway
Primary outcomes
- Vaccination Offer Rate — 12 months
Proportion of patients evaluated by the vaccination service who are offered at least one recommended vaccination. - Vaccination Uptake Rate — 12 months
Proportion of patients who receive at least one vaccination among those evaluated. - Number of Administered Vaccine Doses — 12 months
Number of doses administered by vaccine type - Completion of Hospital-Based Vaccination Pathway — 12 months
Proportion of patients completing all scheduled vaccine doses within the hospital setting.