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NCT07388719
Comparison of Standard Versus Dynamic Compliance-Guided Individualized PEEP in Obese Patients Undergoing Spinal Surgery
NA trial testing Standard PEEP in Obesity in 80 participants. Completed in 12 December 2025.
12 December 2025
Quick facts
| Lead sponsor | Konya City Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 2 February 2025 |
| Primary completion | 12 December 2025 |
| Estimated completion | 12 December 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Standard PEEP
Conditions studied
- Obesity — all drugs for Obesity →
- Postoperative Pulmonary Complications — all drugs for Postoperative Pulmonary Complications →
- Mechanical Ventilation — all drugs for Mechanical Ventilation →
Sponsor
Konya City Hospital
Who can join
Adults 18 to 65, any sex, with Obesity or Postoperative Pulmonary Complications. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to compare standard positive end-expiratory pressure (PEEP) with dynamic compliance-guided individualized PEEP in obese patients undergoing elective spinal surgery under general anesthesia. Obesity and prone positioning during spinal surgery are associated with reduced lung compliance, atelectasis, and an increased risk of postoperative pulmonary complications. Participants will be allocated to receive either a fixed standard PEEP or an individualized PEEP level determined according to intraoperative dynamic lung compliance. Intraoperative oxygenation, respiratory mechanics, arterial blood gas parameters, and hemodynamic variables will be assessed at predefined time points. Postoperative pulmonary complications within the first 24 hours after surgery will also be evaluated. The study seeks to determine whether individualized PEEP titration based on dynamic compliance offers physiological or clinical advantages compared with a standard PEEP strategy in this patient population.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07388719
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Related trials
Other trials of Standard PEEP
Trials testing the same drug.
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- NCT04740151 — Individualized PEEP in Thoracic Surgery · NA · completed
Other recruiting trials for Obesity
Currently open trials in the same condition.
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Other Konya City Hospital trials
Trials by the same sponsor.
- NCT07504705 — Comparison of Intertransverse Process and Erector Spinae Plane Blocks in Acute Postoperative Analgesia Management for La · NA · not yet recruiting
- NCT07525167 — Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data · not yet recruiting
- NCT07335250 — Intertransverse Process Block for Postoperative Analgesia After Thoracotomy and Lobectomy · NA · recruiting
- NCT07511985 — Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty · not yet recruiting
- NCT07295158 — Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07388719 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Konya City Hospital
- Last refreshed: 5 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07388719.
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