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NCT07388407
Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis
trial testing Study for the correlation of SNPs with efficacy and toxicity of Leflunomide in RA patients in Rhematoid Arthritis in 110 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | Foundation University Islamabad |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 110 |
| Start date | 1 September 2024 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 September 2026 |
| Sites | 2 locations across Pakistan |
Drugs / interventions tested
- Study for the correlation of SNPs with efficacy and toxicity of Leflunomide in RA patients — full drug profile →
Conditions studied
- Rhematoid Arthritis — all drugs for Rhematoid Arthritis →
Sponsor
Foundation University Islamabad
Who can join
Adults 20 to 65, any sex, with Rhematoid Arthritis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
1. Patients taking leflunomide as the only disease-modifying anti-rheumatic drug (DMARD) will be recruited after consent. 2. Blood sample for DNA extraction will be taken The patient will be followed up till two visits 3 months apart, and efficacy and toxicity will be checked using DAS28, ultrasonography, and blood tests for ESR, CRP, anti-CCP, liver function tests, etc. The data form for toxicity will be filled. 3. DNA will be extracted in the laboratory, and SNP will be identified. 4. The efficacy and toxicity data will be studied against the SNPs found 5. An algorithm will be constructed for Pakistani RA patients taking leflunomide.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07388407
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Foundation University Islamabad trials
Trials by the same sponsor.
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- NCT07519174 — A Randomized Controlled Trial Comparing the Effectiveness and Safety of Topical Tacrolimus 0.03% Versus Crisaborole 2% i · NA · not yet recruiting
- NCT07526051 — Effects of Autogenic Inhibition Versus Reciprocal Inhibition in Individuals With Lower Cross Syndrome · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07388407 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Foundation University Islamabad
- Last refreshed: 5 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07388407.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing