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NCT07385430
Study of LGW16-03 To Identify Nerves
Phase 1 trial testing LGW16-03 in Adults in 38 participants. Not yet recruiting.
1 August 2027
Quick facts
| Lead sponsor | Eric R. Henderson |
|---|---|
| Phase | Phase 1 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | other |
| Enrollment | 38 |
| Start date | 1 May 2026 |
| Primary completion | 1 August 2027 |
| Estimated completion | 1 August 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- LGW16-03 — full drug profile →
Conditions studied
- Adults — all drugs for Adults →
- Open-field Surgery — all drugs for Open-field Surgery →
- Major Nerve — all drugs for Major Nerve →
Sponsor
Eric R. Henderson — full company profile →
Who can join
18 and older, any sex, with Adults or Open-field Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary goal of this study is to determine the safety and tolerability of LGW16-03, a novel nerve-labeling fluorophore, in participants undergoing open-field orthopaedic surgery. Secondary goals include: 1) identifying the lowest dose without adverse events that provides peak florescence imaging contrast, and 2) characterizing the pharmacokinetics of LGW16-03. Participants will receive a one-time intravenous infusion of the investigational drug (LGW16-03) prior to their planned surgery. Participants' vitals will be closely monitored and will have blood samples taken at regular intervals. Fluorescence images of their major nerve will be taken during surgery. Participants will have one study follow-up visit approximately 30 days after their surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07385430
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07385430 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Eric R. Henderson
- Last refreshed: 18 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07385430.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing