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NCT07381985: LINC
Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural Environment
NA trial testing Longitudinal Cancer Genetics Follow-Up Program in Hereditary Cancer Syndromes in 200 participants. Enrolling by invitation.
1 December 2027
Quick facts
| Lead sponsor | University of Vermont Medical Center |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | health services research |
| Enrollment | 200 |
| Start date | 29 December 2023 |
| Primary completion | 1 December 2027 |
| Estimated completion | 1 December 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Longitudinal Cancer Genetics Follow-Up Program
Conditions studied
- Hereditary Cancer Syndromes — all drugs for Hereditary Cancer Syndromes →
- BRCA1 Hereditary Breast and Ovarian Cancer Syndrome — all drugs for BRCA1 Hereditary Breast and Ovarian Cancer Syndrome →
- Lynch Syndrome — all drugs for Lynch Syndrome →
Sponsor
University of Vermont Medical Center
Who can join
18 and older, any sex, with Hereditary Cancer Syndromes or BRCA1 Hereditary Breast and Ovarian Cancer Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to improve cancer prevention and surveillance adherence in patients with Hereditary Cancer Syndromes (HCS), particularly those living in rural areas. The study will evaluate whether enrolling HCS patients in a longitudinal clinical program with individualized care plans and regular follow-up improves adherence to guideline-recommended cancer screening and risk-reduction strategies. Secondary aims include assessing the program's impact on patient distress and perceived care coordination. The study will enroll 200 adults with known pathogenic germline mutations who were previously seen at the UVM Medical Center genetics clinic. Participants will complete surveys at baseline, 12, and 24 months to assess adherence, distress, and care coordination. Findings from this study will inform future efforts to reduce gaps in hereditary cancer care delivery, especially for rural populations.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07381985
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Vermont Medical Center trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07381985 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Vermont Medical Center
- Last refreshed: 2 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07381985.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing