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NCT07379502
Endometrial Response in Polycystic Ovarian Syndrome Treated With Letrozole Alone or With Added Estradiol Valerate
NA trial testing Letrozole (Aromatase Inhibitors) in PCOS (Polycystic Ovary Syndrome) in 60 participants. Not yet recruiting.
30 June 2026
Quick facts
| Lead sponsor | CMH Kharian Medical College |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 5 March 2026 |
| Primary completion | 30 June 2026 |
| Estimated completion | 31 August 2026 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Letrozole (Aromatase Inhibitors) — full drug profile →
- Letrozole (Aromatase Inhibitors) + Estradiol valerate — full drug profile →
Conditions studied
- PCOS (Polycystic Ovary Syndrome) — all drugs for PCOS (Polycystic Ovary Syndrome) →
Sponsor
CMH Kharian Medical College
Who can join
Adults 20 to 35, female only, with PCOS (Polycystic Ovary Syndrome). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age, characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology. Letrozole, an aromatase inhibitor, has emerged as a first-line ovulation induction agent due to its superior ovulation and pregnancy rates compared to clomiphene citrate. Estradiol valerate, a synthetic estrogen, can be co-administered with letrozole to improve endometrial receptivity by enhancing endometrial thickness, vascularity, and pattern. This study aims to evaluate the effect of letrozole alone versus letrozole with estradiol valerate on endometrial development in these patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07379502
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for PCOS (Polycystic Ovary Syndrome)
Currently open trials in the same condition.
- NCT07197255 — Transcriptomic Profiling of Cumulus Cells From CAPA-IVM · recruiting
- NCT07159880 — Letrozole Extended vs Traditional Therapy for Ovulation Induction in Women With PCOS (PROLEx-PCOS) · NA · recruiting
- NCT07426146 — Feasibility Effects of a Low-GI, High-fibre Diet in PCOS: a Prospective Cohort Study in Remote Yunnan · recruiting
- NCT07448272 — Letrozole 5 mg for 10 Days Versus Letrozole 10 mg for 5 Days for Ovarian Stimulation in PCOS · NA · active not recruiting
- NCT06793085 — Pro- and Anti-inflammatory Cytokines in PCOS · recruiting
Other CMH Kharian Medical College trials
Trials by the same sponsor.
- NCT06996171 — Comparative Efficacy of Magnesium Supplement and Melatonin Congener in Young Adults With Primary Insomnia · NA · recruiting
- NCT06969417 — Comparative Efficacy of Pregabalin and Lacosamide in Patients With Herpes Zoster and Post Herpetic Neuralgia · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07379502 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CMH Kharian Medical College
- Last refreshed: 30 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07379502.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing