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NCT07374952
Minimal Effective Volume 90% for Double-injection Costoclavicular Block
Phase 4 trial testing Ultrasound-guided double-injection costoclavicular nerve block with same previous volume in Brachial Plexus Blocks in 60 participants. Not yet recruiting.
31 December 2026
Quick facts
| Lead sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | quadruple |
| Primary purpose | supportive care |
| Enrollment | 60 |
| Start date | 1 February 2026 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
Drugs / interventions tested
- Ultrasound-guided double-injection costoclavicular nerve block with same previous volume
- Ultrasound-guided double-injection costoclavicular nerve block with lower volume
Conditions studied
- Brachial Plexus Blocks — all drugs for Brachial Plexus Blocks →
- Lidocaine — all drugs for Lidocaine →
- Nerve Block — all drugs for Nerve Block →
- Dose Finding Study — all drugs for Dose Finding Study →
Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Who can join
Adults 18 to 70, any sex, with Brachial Plexus Blocks or Lidocaine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In 2020, a trial demonstrated that a 2-injection technique constitutes the optimal method for the costoclavicular block. This study aims to determine the minimum amount of medication required to achieve a successful double-injection costoclavicular nerve. Block dose assignment will be done using an up-and-down sequential method, called the Biased Coin Design (BCD). The double-injection technique for US-guided costoclavicular block consists in depositing two thirds of the LA volume in the deep compartment (to anesthetize the posterior and medial cords), and one third of the injectate in the superficial compartment (to anesthetize the lateral cord). The ED90 will be calculated using isotonic regression with a 95% confidence interval derived by bootstrapping.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07374952 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McGill University Health Centre/Research Institute of the McGill University Health Centre
- Last refreshed: 20 February 2026
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