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NCT07363980: COTIRA
Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study
trial in Rheumatoid Arthritis in 4,000 participants. Enrolling by invitation.
31 December 2038
Quick facts
| Lead sponsor | Ellen Margrethe Hauge |
|---|---|
| Status | ENROLLING BY INVITATION |
| Study type | OBSERVATIONAL |
| Enrollment | 4,000 |
| Start date | 21 February 2024 |
| Primary completion | 31 December 2038 |
| Estimated completion | 31 December 2040 |
| Sites | 4 locations across Denmark |
Conditions studied
- Rheumatoid Arthritis — all drugs for Rheumatoid Arthritis →
- Atherosclerotic Ischemic Disease — all drugs for Atherosclerotic Ischemic Disease →
- Pulmonary Disease — all drugs for Pulmonary Disease →
- Depressive Disorder — all drugs for Depressive Disorder →
Sponsor
Ellen Margrethe Hauge
Who can join
Adults 50 to 75, any sex, with Rheumatoid Arthritis or Atherosclerotic Ischemic Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that includes comprehensive baseline and follow-up assessments at 3, 5, and 10 years. It comprises a main protocol and several optional modules, including a Cardiac Imaging Module, Biobanking Module, Pulmonary Module, and Anxiety and Depression Module. The study aims to advance understanding of cardiopulmonary and psychological comorbidities in rheumatoid arthritis, to improve early identification and management, and to enhance insights into underlying disease mechanisms-ultimately refining risk stratification and targeted prevention strategies. The study includes 4,000 patients with rheumatoid arthritis enrolled through the Cardiac Imaging Module in the main protocol. Participants undergo coronary computed tomography angiography, pulmonary function testing, physical examination, questionnaires, and biobanking, supplemented by genetic, proteomic, metabolomic, and microbiome profiling.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07363980
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07363980 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ellen Margrethe Hauge
- Last refreshed: 3 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07363980.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing