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NCT07361536
Cardiac Structure and Function in MPS
trial in MPS I in 240 participants. Currently enrolling.
30 April 2030
Quick facts
| Lead sponsor | Children's Hospital of Orange County |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 240 |
| Start date | 1 September 2025 |
| Primary completion | 30 April 2030 |
| Estimated completion | 30 April 2030 |
| Sites | 3 locations across United States |
Conditions studied
- MPS I — all drugs for MPS I →
- MPS IV A — all drugs for MPS IV A →
- MPS - Mucopolysaccharidosis — all drugs for MPS - Mucopolysaccharidosis →
- MPS IVA — all drugs for MPS IVA →
Sponsor
Children's Hospital of Orange County
Who can join
Adults 0 to 99, any sex, with MPS I or MPS IV A. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to better understand how heart and blood vessel problems develop in people with Mucopolysaccharidosis (MPS). The investigators are looking at certain substances in the body called GAGs and proteoglycans to see how they affect the heart. The investigators also want to find reliable blood and urine markers that can help us track heart health and guide future treatments. This study aims to answer two main questions: 1. Do people with MPS show faster changes in their blood vessels over time (such as thickening or stiffening of the carotid artery) compared to people without MPS? 2. Do people with MPS have higher levels of certain proteins in their blood (such as clusterin and inflammatory markers) that are linked to blood vessel changes? What participants will do? Participants will complete the following tests once a year for 4 years: * Carotid ultrasound: an imaging test that looks at the blood vessels in the neck. * Echocardiogram: an ultrasound of the heart. * Blood draw * Urine collection These tests help the investigators track changes in heart and blood vessel health over time.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07361536
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for MPS I
Currently open trials in the same condition.
- NCT04532047 — PEARL (PrEnAtal Enzyme Replacement Therapy for Lysosomal Storage Disorders) · Phase 1 · recruiting
Other Children's Hospital of Orange County trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07361536 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Hospital of Orange County
- Last refreshed: 26 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07361536.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing