NCT07359274

Effects of Neurodynamic and Carpal Bone Mobilization in Mild-to-Moderate Carpal Tunnel Syndrome

Not yet recruiting NA Last updated 22 January 2026

What this trial tests

NA trial testing Neurodynamic mobilization in Carpal Tunnel Syndrome in 93 participants. Not yet recruiting.

Timeline

15 January 2026

Primary endpoint
15 January 2027

15 March 2027

Quick facts

Lead sponsor	Kutahya Health Sciences University
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	93
Start date	15 January 2026
Primary completion	15 January 2027
Estimated completion	15 March 2027
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Neurodynamic mobilization
• Carpal bone mobilization
• Splint

Conditions studied

• Carpal Tunnel Syndrome — all drugs for Carpal Tunnel Syndrome →
• Splints — all drugs for Splints →

Sponsor

Kutahya Health Sciences University

Who can join

Adults 20 to 55, any sex, with Carpal Tunnel Syndrome or Splints. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by compression of the median nerve at the wrist. Conservative interventions such as splinting and manual therapy are frequently used in individuals with mild-to-moderate CTS. Neurodynamic mobilization and carpal bone mobilization aim to improve neural and soft tissue mobility; however, their comparative effects on clinical outcomes and median nerve morphology are not fully understood.

This interventional, non-randomized clinical study aims to compare the clinical and ultrasonographic effects of neurodynamic mobilization plus splinting, carpal bone mobilization plus splinting, and splinting alone in patients with mild-to-moderate CTS. Ninety-three participants diagnosed with mild-to-moderate carpal tunnel syndrome based on electrodiagnostic criteria will be included. Participants will be allocated into three parallel groups without randomization. All participants will receive a neutral-position wrist splint as standard conservative care.

Two intervention groups will additionally receive either neurodynamic mobilization exercises or carpal bone mobilization techniques administered by a physiotherapist for four weeks. Clinical outcomes and median nerve morphology will be evaluated at baseline and immediately after the intervention period.

The primary outcome is the change in the Boston Carpal Tunnel Questionnaire score. Secondary outcomes include pain intensity, neuropathic pain, functional disability, muscle strength, pressure pain threshold, and ultrasonographic measurements of the median nerve.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.