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Preliminary Evaluation of Clinical Application of SPECT Imaging Targeting GPC3
This project will target patients with highly clinically suspected or histopathology diagnosed hepatocellular carcinoma (HCC) using targeted GPC3-specific imaging agents (e.g. , Iodine-131-aGPC3-Scfv) for integrated SPECTCT imaging, to evaluate the pharmacokinetics distribution of the targeted drug in patients with hepatocellular carcinoma (HCC) by low-dose integrated diagnosis and treatment (i.e. , Iodine-131-RRB- imaging, to determine the metabolism, safety and tolerability of the drug in vivo Secondary objective: to evaluate the targeting of GPC3-SPECIFIC imaging agents in patients with hepatocellular carcinoma to assess the feasibility of this targeted agent for future treatment.
Details
| Lead sponsor | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
|---|---|
| Phase | NA |
| Status | NOT_YET_RECRUITING |
| Enrolment | 6 |
| Start date | Fri Jan 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Dec 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- HCC
- SPECT-CT
Interventions
- 131I-aGPC3
Countries
China