The Efficacy of Personalized Local Anesthetic Dosing Based on Ultrasound-Measured Nerve Cross-Sectional Area in Brachial Plexus Block: a Non-Inferiority Randomized Controlled Trial.

NCT07353047 NA NOT_YET_RECRUITING

This is a prospective, randomized, assessor-blinded, three-arm, non-inferiority clinical trial. The study aims to compare the effectiveness and safety of an individualized dosing strategy for local anesthetic in brachial plexus blocks against two standard methods. The experimental intervention uses ultrasound to measure the cross-sectional area (CSA) of the brachial plexus nerves to calculate a patient-specific dose of 0.5% ropivacaine. This is compared to a standard weight-based dosing regimen (2.5 mg/kg) and dosing based on the anesthesiologist's clinical experience. A total of 350 adult patients scheduled for elective unilateral upper limb surgery will be randomly assigned to one of the three groups. The primary outcome is the success rate of the nerve block 30 minutes after administration. Secondary outcomes include assessments of diaphragmatic function, postoperative pain scores, the incidence of complications (such as nerve involvement or systemic toxicity), and patient satisfaction. The hypothesis is that the CSA-based dosing method will be non-inferior to the conventional methods in achieving successful anesthesia while potentially optimizing drug dosage.

Details

Lead sponsor	Northern Jiangsu People's Hospital
Phase	NA
Status	NOT_YET_RECRUITING
Enrolment	300
Start date	Sun Feb 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Wed Sep 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Upper Limb Surgery

Interventions

• CSA-based dosing of Ropivacaine
• Experience-based dosing of Ropivacaine
• Weight-based dosing of Ropivacaine

Countries

China