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NCT07346443
Mechanism Study of G Protein-coupled Receptor 81 in Multiple Organ Dysfunction of Heat Stroke
trial in Heat Stroke in 100 participants. Not yet recruiting.
31 December 2026
Quick facts
| Lead sponsor | Second Affiliated Hospital of Wenzhou Medical University |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 1 March 2026 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 January 2027 |
Conditions studied
- Heat Stroke — all drugs for Heat Stroke →
Sponsor
Second Affiliated Hospital of Wenzhou Medical University
Who can join
Eligibility, any sex, with Heat Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Heat stroke is one of the common acute and critical conditions in the ICU, characterized by a high incidence and mortality rate, and there is still a lack of effective and precise treatment methods. The latest research indicates that G protein-coupled receptor 81 (GPR81), as an endogenous receptor of lactic acid, can regulate immune responses by up-regulating the expression of inflammatory factors and the chemotaxis of neutrophils, suggesting that the GPR81 receptor may play a potential key role in heat stroke. The investigators aim to reveal the position and key role of GPR81 in improving multiple organ dysfunction caused by heat stroke, and to clarify its specific molecular mechanism, with the goal of providing new ideas for the prevention and treatment of heat stroke based on lactate levels, a commonly used clinical indicator.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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Related trials
Other recruiting trials for Heat Stroke
Currently open trials in the same condition.
- NCT06537557 — Application of an Early In-Hospital Temperature Management Protocol for Heat Stroke Patients · NA · recruiting
- NCT06622525 — Use of Sodium Bicarbonate as Prophylaxis for Kidney Damage in Patients With Heatstroke · NA · recruiting
- NCT06192069 — Heat Strain Prevention in Elderly Agricultural Workers · NA · recruiting
Other Second Affiliated Hospital of Wenzhou Medical University trials
Trials by the same sponsor.
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- NCT07530848 — Perioperative Pharmacokinetics of Anesthetic Drugs and Complications in Overweight and Obese Patients · not yet recruiting
- NCT07332793 — Mechanisms of Precise Immune Cell Phenotyping and Prognostic Prediction in Severe Infection · not yet recruiting
- NCT07353970 — Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro- · not yet recruiting
- NCT07424703 — Effect of Bright Light Therapy on Idiopathic Scoliosis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07346443 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Second Affiliated Hospital of Wenzhou Medical University
- Last refreshed: 16 January 2026
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