Last reviewed · How we verify
NCT07342504: Project BEST
Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment
NA trial testing Brief opioid-informed alcohol treatment in Alcohol Use Disorder in 60 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | University of Notre Dame |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 21 January 2026 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 March 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Brief opioid-informed alcohol treatment
Conditions studied
- Alcohol Use Disorder — all drugs for Alcohol Use Disorder →
- Opioid Use Disorder — all drugs for Opioid Use Disorder →
- Alcohol Use — all drugs for Alcohol Use →
- Opioid Use — all drugs for Opioid Use →
Sponsor
University of Notre Dame
Who can join
18 and older, any sex, with Alcohol Use Disorder or Opioid Use Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol. It will also provide initial information on whether the intervention improves outcomes related to alcohol use. The results of this proof-of-concept study will inform whether a future larger clinical trial is warranted.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07342504
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Alcohol Use Disorder
Currently open trials in the same condition.
- NCT06860607 — Environment and Alcohol: A Pilot Study · Phase 1 · recruiting
- NCT07325266 — Human Laboratory Study of Apremilast for Alcohol Use Disorder · Phase 2 · recruiting
- NCT07046819 — Tirzepatide in MetALD · Phase 2 · recruiting
- NCT07279558 — Cannabidiol and Alcohol Use Disorder Phenotypes · Phase 2 · recruiting
- NCT07056894 — Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis · NA · recruiting
Other University of Notre Dame trials
Trials by the same sponsor.
- NCT07156383 — Restorative Effects of Sleep on Everyday Health and Wellbeing: A Treatment Study · NA · not yet recruiting
- NCT05602779 — Leverage Noninvasive Transcutaneous Vagus Nerve Stimulation to Reduce Suicidal Behaviors in Vulnerable Adolescents · NA · active not recruiting
- NCT06732310 — The Unique and Combined Effects of Prenatal and Early Childhood Programming on Child Maltreatment: Examining Mechanisms · Phase 2 · enrolling by invitation
- NCT05706376 — An Evidence-based Family Support Program for Parents and Children in Palestine: a Theory-based Intervention · NA · recruiting
- NCT05452447 — Spatial Repellents for Aedes-borne Virus Control in Sri Lanka · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07342504 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Notre Dame
- Last refreshed: 15 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07342504.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing