"The Effect of Probiotics on the Degree of Dyspnea, Lung Function, and Inflammatory Mediators in Patients With Chronic Obstructive Pulmonary Disease (COPD)."

NCT07339280 NA ENROLLING_BY_INVITATION

The goal of this randomized, placebo controlled, double-blind clinical trial is to find out whether a probiotic supplement can help adults with chronic obstructive pulmonary disease (COPD) breathe better and better control their symptoms. The study will try to answer does taking a probiotic supplement, compare with a placebo, reduce shortness of breath, does it improve daily COPD symptoms or change stool patterns by using validated questionnaires; does it affect lung function or inflammation. The results of this study may contribute to a better understanding of the disease, the application of new therapeutic options, and provide a foundation for future research.

Details

Lead sponsor	University Hospital of Split
Phase	NA
Status	ENROLLING_BY_INVITATION
Enrolment	60
Start date	2026-03-08
Completion	2030-12

Conditions

• COPD
• COPD (Chronic Obstructive Pulmonary Disease)
• Probiotic
• Probiotic Supplement

Interventions

• Probiotic Capsule
• placebo capsule

Primary outcomes

• mMRC scale of dyspnea — 8 weeks
  The primary objective of this study is to assess the degree of change in dyspnea, measured using the validated mMRC (Modified Medical Research Council) questionnaire in patients with COPD eight weeks after administration of the probiotic dietary supplement.

Countries

Croatia