Cognitively-enhanced tDCS of the Dorsolateral Prefrontal Cortex to Reduce Craving in Cocaine Addiction

NCT07318480 NA RECRUITING

The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder. Neuroimaging before and after stimulation will establish the neural correlates of recovery and allow predictions of outcomes, which will be assessed throughout the study and one month after its completion. Results could pave the way towards development of a new self-administered intervention to reduce craving when it is needed the most, enhancing recovery real-time and in the natural environment in people with cocaine addiction as generalizable to other drugs of abuse and other disorders of self-control.

Details

Lead sponsor	Icahn School of Medicine at Mount Sinai
Phase	NA
Status	RECRUITING
Enrolment	120
Start date	2026-02-25
Completion	2030-02

Conditions

• Cocaine Use Disorder
• Cocaine Dependence
• Substance Use Disorder (SUD)

Interventions

• Transcranial Direct Current Stimulator (tDCS)
• Cognitive Reappraisal Training

Primary outcomes

• fMRI blood-oxygenation level dependent (BOLD) signal — At baseline and immediately after 5 weeks of tDCS.
  Neuroimaging - Measure of fMRI blood-oxygenation level dependent (BOLD) signal in the dorsolateral prefrontal cortex before and immediately after 5 weeks of tDCS.
• Change in Self-Reported Craving Score — At baseline, immediately after 5 weeks of tDCS, and 1 month after interventions.
  Changes in measures of craving cocaine craving on a 0-9 point scale in response to interventions, with high scores indicating higher craving.

Countries

United States