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NCT07316023
Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management
Phase 2 trial testing Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles in Stage III Periodontitis in 27 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | Nada Mahmoud Soliman |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 27 |
| Start date | 15 January 2026 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 August 2026 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles
- Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded macroparticles — full drug profile →
- Non- surgical periodontal therapy only
Conditions studied
- Stage III Periodontitis — all drugs for Stage III Periodontitis →
Sponsor
Nada Mahmoud Soliman — full company profile →
Who can join
Adults 36 to 50, any sex, with Stage III Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To better understand and treat your gum disease, dentists now use a system that stages its severity and grades its speed, rather than using old labels. The recommended first step is almost always a deep cleaning, which is very effective. However, because some bacteria can hide from cleanings and antibiotics, researchers are exploring a promising light-based treatment. This method uses a safe, light-activated dye and a gentle laser to target and kill bacteria without leading to resistance. To make this treatment even stronger, scientists are testing a way to package the dye inside tiny, biodegradable "containers" that deliver it directly to the germs. The goal of this research is to see if this advanced delivery method works better than the dye alone, hoping to provide a more powerful, non-surgical option to fight gum disease and protect your teeth."
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07316023
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Stage III Periodontitis
Currently open trials in the same condition.
- NCT07438977 — Evaluation of Serum TRACP-5b, BALP, and 25-Hydroxyvitamin D3 Levels in Stage III Periodontitis Patients · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07316023 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nada Mahmoud Soliman
- Last refreshed: 5 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07316023.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing