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NCT07311447: TCI-NEURO
Target-Controlled Infusion and Postoperative Neurocognitive Outcomes in Geriatric Patients
trial in Postoperative Cognitive Dysfunction (POCD) in 50 participants. Completed in 31 October 2025.
31 October 2025
Quick facts
| Lead sponsor | Namigar Turgut |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 5 May 2025 |
| Primary completion | 31 October 2025 |
| Estimated completion | 31 October 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Postoperative Cognitive Dysfunction (POCD) — all drugs for Postoperative Cognitive Dysfunction (POCD) →
- Neurocognitive Function — all drugs for Neurocognitive Function →
- Sedation and Analgesia — all drugs for Sedation and Analgesia →
- Geriatric Patients — all drugs for Geriatric Patients →
Sponsor
Namigar Turgut
Who can join
65 and older, any sex, with Postoperative Cognitive Dysfunction (POCD) or Neurocognitive Function. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This prospective observational study aims to evaluate the effects of target-controlled infusion (TCI) on postoperative neurocognitive function in geriatric patients undergoing major non-cardiac surgery. Elderly patients are at increased risk of postoperative cognitive dysfunction due to physiological changes and anesthesia-related factors. In this study, sedation management with TCI will be compared to manual infusion. Neurocognitive function will be assessed at multiple time points using the Mini-Mental State Examination (MMSE), and sedation levels will be monitored with the Bispectral Index (BIS) and the Richmond Agitation-Sedation Scale (RASS). The study aims to provide insights into safer sedation practices and improved cognitive outcomes in elderly surgical patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07311447
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other Namigar Turgut trials
Trials by the same sponsor.
- NCT04010474 — Surgical APGAR Score and Modified Surgical APGAR Score · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07311447 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Namigar Turgut
- Last refreshed: 31 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07311447.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing