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NCT07301749: EXPAND
A Clinical Study Evaluating the Safety and Efficacy of the VCFix Spinal System for Treatment of Vertebral Compression Fractures.
NA trial testing VCFix Spinal System in stand-alone configuration in Vertebral Compression Fracture in 103 participants. Currently enrolling.
31 July 2027
Quick facts
| Lead sponsor | Amber Implants B.V. |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 103 |
| Start date | 4 November 2025 |
| Primary completion | 31 July 2027 |
| Estimated completion | 31 December 2028 |
| Sites | 3 locations across France, Germany |
Drugs / interventions tested
- VCFix Spinal System in stand-alone configuration
Conditions studied
- Vertebral Compression Fracture — all drugs for Vertebral Compression Fracture →
Sponsor
Amber Implants B.V.
Who can join
Adults 21 to 85, any sex, with Vertebral Compression Fracture. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary objective of the EXPAND clinical investigation is to evaluate the safety and efficacy of the VCFix Spinal System for the treatment of Vertebral Compression Fractures. The study aims to demonstrate a reduction in vertebral fracture-related pain and an improvement in physical function and mobility, while ensuring the absence of (serious) adverse events ((S)AE) related to the device or procedure.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07301749
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of VCFix Spinal System in stand-alone configuration
Trials testing the same drug.
- NCT07259811 — Vertebral Augmentation Using VCFix Spinal System in Stand-alone Configuration · NA · active not recruiting
Other recruiting trials for Vertebral Compression Fracture
Currently open trials in the same condition.
- NCT07259811 — Vertebral Augmentation Using VCFix Spinal System in Stand-alone Configuration · NA · active not recruiting
- NCT04835428 — STAND - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures · NA · recruiting
- NCT04821739 — RISE - Study of the AGN1 LOEP SV Kit in Patients With Vertebral Compression Fractures · NA · recruiting
- NCT07507565 — Comparison of Analgetic Therapies in Traumatic Vertebral Compression Fractures: Vertebroplasty vs Thermal Facet Ablation · NA · active not recruiting
Other Amber Implants B.V. trials
Trials by the same sponsor.
- NCT07259811 — Vertebral Augmentation Using VCFix Spinal System in Stand-alone Configuration · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07301749 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Amber Implants B.V.
- Last refreshed: 24 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07301749.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing