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NCT07299240
Remote Ischemic Conditioning for Sleep Disturbances and Other Non-motor Symptoms in Parkinson's Disease
NA trial testing Remote ischemic conditioning device in Parkinson Disease (PD) in 48 participants. Not yet recruiting.
31 December 2026
Quick facts
| Lead sponsor | Jiangsu Province Nanjing Brain Hospital |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 48 |
| Start date | 1 January 2026 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Remote ischemic conditioning device
- Sham remote ischemic conditioning
Conditions studied
- Parkinson Disease (PD) — all drugs for Parkinson Disease (PD) →
- Insomnia — all drugs for Insomnia →
Sponsor
Jiangsu Province Nanjing Brain Hospital
Who can join
Adults 50 to 70, any sex, with Parkinson Disease (PD) or Insomnia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This single-center, randomized, single-blind, sham-controlled clinical trial aims to evaluate whether remote ischemic conditioning (RIC) can improve sleep disturbances and other non-motor symptoms in patients with Parkinson's disease (PD). Forty-eight PD patients with insomnia will be randomly assigned in a 1:1 ratio to receive either active RIC (cuff inflation to high pressure) or sham RIC (cuff inflation to low pressure) for 7 consecutive days, in addition to their standard antiparkinsonian medications. Subjective sleep scales, sleep diaries, validated rating scales for motor and non-motor symptoms, and overnight polysomnography will be used to assess treatment effects at baseline, after the 7-day intervention, and during short-term follow-up. The study will also explore potential mechanisms of RIC by combining EEG, functional MRI, retinal optical coherence tomography, and blood biomarkers.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07299240
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Parkinson Disease (PD)
Currently open trials in the same condition.
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- NCT07302386 — Exercise Management in Parkinson's Disease · NA · recruiting
- NCT07157345 — Testing if PDR-001 Can Safely and Effectively Remove Harmful Brain Protein in Parkinson's Disease · Phase 1 · recruiting
Other Jiangsu Province Nanjing Brain Hospital trials
Trials by the same sponsor.
- NCT07317557 — Remote Ischemic Conditioning for Cognitive Impairment in Cerebral Small Vessel Disease · NA · not yet recruiting
- NCT07480317 — TIS for Brain Network Modulation and Clinical Efficacy in Parkinson's Disease · NA · not yet recruiting
- NCT07323121 — 40 Hz Flickering for Insomnia in Parkinson's Disease · NA · not yet recruiting
- NCT07492472 — The Effects of Low-Intensity Music in Adolescents With Anxiety · NA · recruiting
- NCT07246044 — HD-tDCS for Adolescent Bipolar Depression Targeting S1 · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07299240 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Jiangsu Province Nanjing Brain Hospital
- Last refreshed: 30 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07299240.
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