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NCT07292363
Inflammation-Related Endothelial Barrier Dysfunction in Patients With Apical Periodontitis
trial testing Apical lesions cure in Apical Periodontitis in 45 participants. Completed in 16 October 2025.
30 April 2022
Quick facts
| Lead sponsor | University of Turin, Italy |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 45 |
| Start date | 9 February 2021 |
| Primary completion | 30 April 2022 |
| Estimated completion | 16 October 2025 |
| Sites | 2 locations across Italy |
Drugs / interventions tested
- Apical lesions cure
Conditions studied
- Apical Periodontitis — all drugs for Apical Periodontitis →
- Healhty — all drugs for Healhty →
Sponsor
University of Turin, Italy
Who can join
Adults 25 to 55, any sex, with Apical Periodontitis or Healhty. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Inflammation is a common factor in chronic periodontitis and systemic diseases. However, to date, there is no scientific evidence supporting a causal effect of inflammation caused by apical periodontitis on endothelial barrier dysfunction. A case-control study was designed to evaluate serum levels of endothelial barrier dysfunction factors in a sample of healthy patients aged 25 to 55, with or without apical periodontitis, before endodontic treatment and 6 and 12 months after treatment. The aim of this study is to investigate the potential relationship between the presence of chronic endodontic lesions and inflammation-related alterations of the endothelial barrier that may compromise its integrity, as well as to determine whether endodontic treatment can reduce these factors, thereby preventing changes in endothelial permeability.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07292363
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Apical Periodontitis
Currently open trials in the same condition.
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Other University of Turin, Italy trials
Trials by the same sponsor.
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- NCT07311291 — The Effect of Different Hemostatic Agents on Hemorrhage Control, Pain and Quality of Life After Endodontic Microsurgery. · NA · completed
- NCT06904963 — Efficacy of Oral Hygiene Instructions Carried Out Using an Intra-oral Scanner · NA · completed
- NCT07047261 — Efficacy of a Xanthan-based Chlorhexidine Gel in the Treatment of Peri-implant Mucositis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07292363 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Turin, Italy
- Last refreshed: 31 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07292363.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing