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NCT07287956
The Use of Adjunct Oxygen High-Level Laser Therapy on the Clinical and Microbiological Outcomes of Peri-implant Disease
NA trial testing Oxygen high-level laser therapy (Diode laser and hydrogen peroxide) in Peri-Implantitis and Peri-implant Mucositis in 16 participants. Completed in 1 August 2025.
7 July 2025
Quick facts
| Lead sponsor | King Abdullah University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 16 |
| Start date | 5 February 2024 |
| Primary completion | 7 July 2025 |
| Estimated completion | 1 August 2025 |
| Sites | 1 location across Jordan |
Drugs / interventions tested
- Oxygen high-level laser therapy (Diode laser and hydrogen peroxide)
- Diode laser therapy
Conditions studied
- Peri-Implantitis and Peri-implant Mucositis — all drugs for Peri-Implantitis and Peri-implant Mucositis →
Sponsor
King Abdullah University Hospital
Who can join
18 and older, any sex, with Peri-Implantitis and Peri-implant Mucositis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to learn whether using a special light-activated treatment called photodynamic therapy, or more specifically, its modified version called oxygen high-level laser therapy, using a high-powered diode laser along with 3% hydrogen peroxide, can improve gum health around dental implants. It tests whether adding this to regular cleaning treatments could reduce harmful bacteria and support better healing. The aim is to determine whether a specific protocol is an effective way to treat infections around dental implants. Participants in the study will receive two types of treatment on different dental implants: * One implant will be treated with the oxygen high-level laser therapy using diode laser and hydrogen peroxide after mechanical cleaning. * The other implant will receive diode laser therapy without hydrogen peroxide after mechanical cleaning. Researchers will compare how the gums respond to each treatment, looking at signs such as inflammation, and determine whether the number of harmful bacteria has been reduced at three time points.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07287956
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Peri-Implantitis and Peri-implant Mucositis
Currently open trials in the same condition.
- NCT07104760 — Longitudinal Evaluation of Regenerative Treatment of Peri-implantitis Assited by Er,Cr:YSGG Laser: up to 10 Years Follow · active not recruiting
- NCT06884475 — Evaluation of Implantoplasty in the Treatment of Peri-Implantitis. · NA · active not recruiting
- NCT06740123 — Evaluation of Hydrogel Application in the Treatment of Periodontitis and Peri-implantitis · NA · active not recruiting
Other King Abdullah University Hospital trials
Trials by the same sponsor.
- NCT07429916 — Ketamine for Shoulder Pain Following Laparoscopic Gastric Sleeve Surgery · EARLY_PHASE1 · recruiting
- NCT06884787 — Color Adjusting Resin Composite in Anterior Tooth Restorations: Clinical and Subjective Evaluations · NA · recruiting
- NCT06884813 — Clinical Evaluation of Color-Adjusting Composite Resin Following In-Office Dental Bleaching · NA · recruiting
- NCT07173296 — The Effect of Bleaching Application Mode on Bleaching-induced Tooth Sensitivity. · NA · recruiting
- NCT07355517 — Guided Biofilm Therapy Compared to Traditional Cleaning for Treating Gingival Inflammation in Orthodontic Patients · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07287956 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by King Abdullah University Hospital
- Last refreshed: 17 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07287956.
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