NCT07281053

E-PRF vs Collagen Membranes in Ridge Preservation

Completed NA Last updated 15 December 2025

What this trial tests

NA trial testing Barrier membrane for ridge preservation in Ridge Preservation in 55 participants. Completed in 6 November 2025.

Timeline

20 February 2025

Primary endpoint
1 November 2025

6 November 2025

Quick facts

Lead sponsor	Center for Advanced Rejuvenation and Esthetics
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	55
Start date	20 February 2025
Primary completion	1 November 2025
Estimated completion	6 November 2025
Sites	1 location across United States

Drugs / interventions tested

• Barrier membrane for ridge preservation

Conditions studied

• Ridge Preservation — all drugs for Ridge Preservation →

Sponsor

Center for Advanced Rejuvenation and Esthetics — full company profile →

Who can join

Eligibility, any sex, with Ridge Preservation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Dental implants are often considered the gold standard to replace missing teeth. Having success with dental implants depends on the hard tissue and soft tissue remaining after tooth extractions. The first step to successful dental implant placement begins with proper socket grafting which includes placing a bone graft and membrane among other biomaterials such as platelet-rich fibrin (PRF) to prevent the collapse of the ridge that occurs after a dental extraction.

While platelet-rich fibrin is commonly utilized for ridge preservation, it is often used in conjunction with a collagen membrane due to the fact that it has a short resorption time lasting roughly 2 weeks. However, recently, it was discovered that by heating the plasma layer and denaturing the albumin, the resorption properties of PRF could be extended from 2 weeks to 4-6 months. This extended platelet-rich fibrin (e-PRF) membrane is a promising replacement to collagen membranes in various surgeries. The investigators previously demonstrated that e-PRF is a safe and feasible alternative to conventional membranes with 4 different iterations of applying the novel e-PRF membrane. However, there still lacks a comparative study to traditional collagen membranes and between the 4 different iterations.

Four different techniques utilizing e-PRF membranes for ridge augmentation will be performed with a collagen membrane as a control group. These techniques include 1) e-PRF as a sole barrier membrane, 2) layering a solid-PRF membrane over the e-PRF membrane, 3) fabricating e-PRF intra-orally in gel form as a Bio-Filler, and 4) Fabricating the e-PRF membrane intra-orally under a solid-PRF membrane.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.