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NCT07277465: MICROOBAR
Role of the Microbiota in Obesity: Effect After Bariatric Surgery
NA trial testing Bariatric surgery in Obese Patients With Bariatric Surgery in 60 participants. Completed in 31 May 2025.
31 January 2025
Quick facts
| Lead sponsor | Celia Bañuls |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 3 March 2021 |
| Primary completion | 31 January 2025 |
| Estimated completion | 31 May 2025 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Bariatric surgery
Conditions studied
- Obese Patients With Bariatric Surgery — all drugs for Obese Patients With Bariatric Surgery →
Sponsor
Celia Bañuls — full company profile →
Who can join
Adults 18 to 65, any sex, with Obese Patients With Bariatric Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Several studies have demonstrated that bariatric surgery is effective for inducing weight loss in obese patients. In addition, the effects of this surgery on multiple associated alterations are well known, including changes in the secretion and activity of hormones involved in appetite regulation, satiety, and energy expenditure, as well as alterations in the gut microbiota composition. However, in cases of severe obesity, recent data have challenged the prevailing view, as bacterial species associated with low microbial richness (prior to surgery) appear to change only marginally after bariatric surgery, despite significant metabolic improvements. Our objective is to examine whether gut microbiota and gastrointestinal peptides are further impaired in severe obesity and, additionally, to explore how the microbiota relates to metabolic profile or sex, as well as whether bariatric surgery may differentially correct obesity-related intestinal microbial features. To this end, we propose a prospective, interventional, translational clinical study involving a cohort of 60 obese patients (BMI \> 35 kg/m²) undergoing laparoscopic gastric bypass surgery. Patients will be grouped according to their degree of obesity to assess potential baseline differences and to evaluate the efficacy of the intervention. Furthermore, we will investigate whether these parameters differ according to metabolic profile or sex. Body composition and nutritional status will be assessed, along with cardiovascular risk factors and comorbidities (hypertension, obstructive sleep apnea syndrome, dyslipidemia, type 2 diabetes mellitus, and insulin resistance). Gastrointestinal hormones (ghrelin, GIP, GLP-1, PYY, CCK, and leptin) will be measured in serum using Luminex XMAP technology. The content and diversity of the gut microbiota will be analyzed (16S rRNA amplicon sequencing and shotgun metagenomic sequencing using Illumina MiSeq technology) in stool samples collected before and 6-12 months after surgery. Additionally, individualized dietary follow-up and assessment of participants' quality of life will be conducted.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07277465
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Bariatric surgery
Trials testing the same drug.
- NCT06564610 — Laparoscopic Transversus Abdominis Plane Block Versus Erector Spinae Plane Block in Bariatric Surgery · NA · completed
- NCT07289555 — Tailored Stapled SADI-S: Initial Report and Preliminary Results · NA · recruiting
- NCT06874309 — Non-invasive Brain Stimulation to Prepare the Patient for Bariatric Surgery (REBAS) · NA · recruiting
- NCT06346145 — Impact of Bariatric Surgery on Heart Disease Compared to Standard Care · NA · not yet recruiting
- NCT06420479 — The Causal Effect of Bariatric Surgery on Cardiovascular Disease and Mortality · recruiting
Other recruiting trials for Obese Patients With Bariatric Surgery
Currently open trials in the same condition.
- NCT06950112 — Comparison Between Individualized PEEP Ventilation Guided by Driving Pressure and Conventional Lung Protective Strategy · NA · recruiting
- NCT07070908 — Modifications to Gastric Sleeve: Implications for GRED and Quality of Life · NA · active not recruiting
Other Celia Bañuls trials
Trials by the same sponsor.
- NCT06901739 — Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity. · NA · recruiting
- NCT06551285 — Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of L · NA · recruiting
- NCT06680635 — Effect of Citrus Flavonoids on Obesity. · NA · completed
- NCT06279780 — Gut Microbiota, Mitochondrial Function and Metabolic Health in Obesity · NA · completed
- NCT07481942 — Body Composition Assessment in Transgender Population. · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07277465 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Celia Bañuls
- Last refreshed: 18 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07277465.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing