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NCT07271654
Can Pretreatment With Analgesics Reduce Postendodontic Pain?
NA trial testing Pre treatment with NSAIDS in Pulpitis - Irreversible in 160 participants. Completed in 1 October 2025.
1 October 2025
Quick facts
| Lead sponsor | College of Physicians and Surgeons Pakistan |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 160 |
| Start date | 1 August 2025 |
| Primary completion | 1 October 2025 |
| Estimated completion | 1 October 2025 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Pre treatment with NSAIDS
- No pretreatment with NSAIDS.
Conditions studied
- Pulpitis - Irreversible — all drugs for Pulpitis - Irreversible →
Sponsor
College of Physicians and Surgeons Pakistan
Who can join
Adults 18 to 65, any sex, with Pulpitis - Irreversible. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled trial investigated whether a single dose of diclofenac sodium taken before a root canal procedure can reduce pain in the hours following the treatment. 160 patients with tooth pain from irreversible pulpitis were divided into two groups. One group received 100mg of diclofenac sodium 30 minutes before their procedure, while the other group received no pretreatment. Pain levels were measured at 6, 12, and 24 hours after the procedure. The study found that patients who took diclofenac before treatment were significantly more likely to be pain-free at 6 and 12 hours after the procedure compared to those who did not.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07271654
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Pulpitis - Irreversible
Currently open trials in the same condition.
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- NCT07340606 — The Role of the Pre-operative Condition and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full · NA · recruiting
- NCT07375576 — Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis · NA · recruiting
- NCT07306533 — Effect of Menstrual Phase on the Anesthetic Efficacy · NA · recruiting
- NCT07130214 — The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy · active not recruiting
Other College of Physicians and Surgeons Pakistan trials
Trials by the same sponsor.
- NCT07271511 — Postoperative Pain After Single vs Multiple-Visit Root Canal Treatment in Diabetic Patients · NA · not yet recruiting
- NCT07453160 — Comparing Two Root Canal Cleaning Solutions (Chlorhexidine vs. Sodium Hypochlorite) for Pain After Treatment · NA · not yet recruiting
- NCT07239752 — Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars · NA · not yet recruiting
- NCT07277426 — Comparing Two Surgical Methods to Prevent Pterygium Regrowth · NA · not yet recruiting
- NCT07247630 — Comparison of Permethrin-Based Treatment Strategies Against Scabies in Infants and Young Children · EARLY_PHASE1 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07271654 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by College of Physicians and Surgeons Pakistan
- Last refreshed: 9 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07271654.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing