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Association Between Vitamin D Deficiency and Disease Activity in Patients With Inflammatory Bowel Disease
Crohn's disease (CD) and ulcerative colitis (UC) are two major types of inflammatory bowel disease (IBD) that are identified by different clinical, endoscopic, pathological, and radiologic diagnostic methods. In the past few years, the incidence of inflammatory bowel disease has been increasing worldwide, with the incidence of UC being higher than that of CD. Vitamin D is a fat-soluble vitamin that is produced in the skin by a UV-dependent reactionand then hydroxylated by the kidneys and liver, and is converted to its active form, 1,25-dihydroxyvitamin D. Vitamin D deficiency is common throughout the world and its deficiency rates ranging from 30 to 50% have been reported. Several studies have shown the role of vitamin D as a regulator of the immune system and its inhibitory function incellular immunity and production of pro-inflammatory cytokines that play a major role in autoimmune diseases. In some human studies, the link between vitamin D levels and the disease severity of IBD has been shown, but it is not clear whether lack of vitamin D is the cause or consequence. In this study, we aimed to investigate the relationship between inflammatory bowel disease and itsflare-up with serum levels of vitamin D
Details
| Lead sponsor | Assiut University |
|---|---|
| Status | NOT_YET_RECRUITING |
| Enrolment | 100 |
| Start date | 2026-01 |
| Completion | 2027-06 |
Conditions
- Inflammatory Bowel Diseases
Interventions
- Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate
Primary outcomes
- Prevalence of vitamin D deficiency in patients with active inflammatory bowel disease — Recent vitamin D and disease activity assessment (within 1 month)
This will be done by measuring the vitamin D level in the serum of patients with active inflammatory bowel diseases (in nanograms/ milliliter)