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NCT07258732: PROBE
The Impact of Probiotics on Bariatric Treatment Outcomes
NA trial testing Probiotic in Obesity &Amp; Overweight in 200 participants. Participants enrolled and being followed up; not accepting new ones.
10 July 2026
Quick facts
| Lead sponsor | University of Warmia and Mazury in Olsztyn |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 200 |
| Start date | 10 July 2025 |
| Primary completion | 10 July 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- Probiotic
- Diet
Conditions studied
- Obesity &Amp; Overweight — all drugs for Obesity &Amp; Overweight →
Sponsor
University of Warmia and Mazury in Olsztyn
Who can join
18 and older, any sex, with Obesity &Amp; Overweight. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The planned study aims to assess whether probiotics improve the quality of life in patients during the early postoperative period following sleeve gastrectomy, and whether they influence the absorption of micro- and macronutrients. Patients eligible for inclusion will have a BMI of 40 kg/m² or higher and must have successfully completed the qualification process for sleeve gastrectomy. Exclusion criteria include chronic gastrointestinal diseases, antibiotic use within 4 weeks prior to surgery, and lack of consent to participate in the study. On the day before surgery, a stool sample will be collected from each patient for microbiological analysis to assess the composition of gut bacteria. Patients will then undergo sleeve gastrectomy using a standard surgical technique. After the operation, participants will be randomized into two groups. The first group will receive probiotics containing Bifidobacterium animalis AMT30, Bifidobacterium breve AMT32, and Lactobacillus plantarum AMT14. These strains are deposited in the Polish Collection of Microorganisms at the Polish Academy of Sciences in Wrocław and are protected by Polish, European, and U.S. patents. The second group will receive a placebo. As part of follow-up, stool samples will be collected again one month and three months after surgery for comparative microbiological analysis.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07258732
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Obesity &Amp; Overweight
Currently open trials in the same condition.
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Other University of Warmia and Mazury in Olsztyn trials
Trials by the same sponsor.
- NCT06610253 — Evaluation of the Impact of the Consumption of Plant-derived Protein Supplements Compared to Animal-derived Proteins · NA · completed
- NCT05486169 — Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy · NA · completed
- NCT06081413 — Bariatric and Metabolic Surgery in Patients Over 65 Years of Age · completed
- NCT07176299 — Unilateral Laparoscopic TAP Block vs. Local Infiltration in Post-Cholecystectomy Analgesia · NA · completed
- NCT04845386 — : A Comparison of Neuromuscular Transmission in the Muscles During General Anesthesia · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07258732 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Warmia and Mazury in Olsztyn
- Last refreshed: 2 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07258732.
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