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NCT07257406
Dexamethasone for Post-operative Pain After Cesarean Delivery Under Neuraxial Anesthesia.
NA trial testing Dexamethasone (IV) in Pregnancy in 87 participants. Completed in 1 October 2025.
8 June 2021
Quick facts
| Lead sponsor | Valerie Zaphiratos |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 87 |
| Start date | 13 September 2018 |
| Primary completion | 8 June 2021 |
| Estimated completion | 1 October 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Dexamethasone (IV) — full drug profile →
- Placebo
Conditions studied
- Pregnancy — all drugs for Pregnancy →
- Cesarean Delivery — all drugs for Cesarean Delivery →
- Dexamethasone — all drugs for Dexamethasone →
Sponsor
Valerie Zaphiratos
Who can join
18 and older, female only, with Pregnancy or Cesarean Delivery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
After surgery pain in women who have had a cesarean delivery is a determining factor in the quality and duration of their hospital stay. Insufficient pain relief can lead to longer hospitalization and long term pain, which can result in long term use of pain medication. A classic method to alleviate pain after cesarean delivery is by injecting morphine into the spinal fluid, in the women's back, in addition to prescribing morphine by mouth as needed after the surgery. However, the negative effects associated with morphine and morphine-like drugs, limit the doses used, their pain relief capacity, and can negatively affect the after surgical experience of women. An approach which uses pain relief that acts on different pain pathways to treat after surgery pain helps limit the negative effects of different drugs. The potential benefit of dexamethasone as pain relief in women who have had a cesarean delivery is all the more interesting because of its minimal negative effects compared to morphine-like drugs. Its low cost, its effectiveness to prevent nausea, and its impact on the general condition of patients make dexamethasone even more attractive.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07257406
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07257406 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Valerie Zaphiratos
- Last refreshed: 8 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07257406.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing