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NCT07256028: IAA-EED

Indispensable Amino Acids Bioavailability in Children With Environmental Enteropathy Dysfunction (IAA-EED)

Not yet recruiting NA Last updated 1 December 2025
What this trial tests

NA trial testing Indispensable amino acids supplemntation in Environmental Enteric Dysfunction in 40 participants. Not yet recruiting.

Timeline
10 December 2025
Primary endpoint
31 March 2026
31 July 2026

Quick facts

Lead sponsorMorocco's National Centre for Energy, Sciences and Nuclear Techniques
PhaseNA
StatusNot yet recruiting
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposesupportive care
Enrollment40
Start date10 December 2025
Primary completion31 March 2026
Estimated completion31 July 2026
Sites1 location across Morocco

Drugs / interventions tested

Conditions studied

Sponsor

Morocco's National Centre for Energy, Sciences and Nuclear Techniques

Who can join

Adults 18 Months to 36 Months, any sex, with Environmental Enteric Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In Morocco, large efforts have been made to enhance nutritional status and health conditions of children. Accordingly, stunting was reduced and the prevalence of stunting have decreased from 28,6% in 1987 to 14,9% in 2011. Many factors, including improved nutrition, have influenced this decrease, and are reinforced to maintain this low prevalence of stunting. Of interest, quality diet, specifically with reference to its protein quality, has contributed to improve the nutritional status of the Moroccan population. However, infectious diseases are still important and in some areas many children are of high risk to develop EED that alter intestinal permeability and microbial translocation, and lead to systemic inflammation. During childhood, protein supply is of a great interest and indigestibility of these proteins and/or malabsorption of indispensable amino acids will affect children growth and many physiological and cognitive functions. This project was planned to assess indispensable amino acids during EED and to to assess the impact of some interventions (amino acids supplementation / medical treatment) on the nutritional status of children. This study will be carried out according to a trilogy of close collaboration between CNESTEN, Pr Claire Gaudichon from AgroParisTech (France) who will provide technical assistance and scientific accompaniment during the progress of the project, she will also participate in the data analysis, exploitation and valorization of results and the department of Pediatric Hepatology Gastroenterology and Nutrition-P III at the Children's Hospital in Rabat.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials.
    Lee GO, Owino V, Baquiran AFP, Pasanna RM, et al · · 2026 · PMID 42031499 · DOI 10.1136/bmjopen-2025-105456

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Data sources for this page

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