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NCT07255521: PREHAB-HSCT
Prehabilitation to Improve Frailty, Function, and Quality of Life in Candidates for Hematopoietic Stem Cell Transplantation
NA trial testing Multimodal Prehabilitation in Hematopoietic Stem Cell Transplantation (HSCT) in 68 participants. Not yet recruiting.
29 May 2026
Quick facts
| Lead sponsor | Hospital del Salvador |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 68 |
| Start date | 26 December 2025 |
| Primary completion | 29 May 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 2 locations across Chile |
Drugs / interventions tested
- Multimodal Prehabilitation
Conditions studied
- Hematopoietic Stem Cell Transplantation (HSCT) — all drugs for Hematopoietic Stem Cell Transplantation (HSCT) →
Sponsor
Hospital del Salvador
Who can join
18 and older, any sex, with Hematopoietic Stem Cell Transplantation (HSCT). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Candidates for hematopoietic stem cell transplantation (HSCT) frequently experience declines in strength, physical function, and quality of life before the procedure. Many also present fatigue, limitations in daily activities, and an increased risk of complications during and after hospitalization. Optimizing physical condition before transplantation may improve post-procedure recovery. This study will evaluate whether a prehabilitation program improves physical function, frailty, and quality of life in adults preparing for HSCT. The intervention consists of supervised exercise, education, and activities designed to enhance endurance and functional capacity. Although prehabilitation has shown benefits in other oncologic populations, it has been minimally studied in HSCT candidates, and no structured programs have been evaluated in Chile. A total of 68 adults will be randomly assigned to a prehabilitation group or a usual-care control group. The prehabilitation group will receive a personalized program including aerobic and resistance exercise, stretching, balance training, respiratory exercises, and education on healthy behaviors, delivered through a hybrid model of in-person and remote sessions. Occupational therapy will also be provided to support functional and cognitive abilities. The control group will continue with standard medical care. Baseline and post-intervention assessments will include measures of strength, frailty, fatigue, balance, cognitive function, daily activities, and quality of life. Post-transplant outcomes such as hospital length of stay, complications, and readmissions within three months will also be recorded. Feasibility, adherence, satisfaction, and adverse events will be evaluated. Findings from this trial may inform the development of structured prehabilitation programs for HSCT candidates and support the implementation of evidence-based supportive care strategies in hematologic oncology.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07255521
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other trials of Multimodal Prehabilitation
Trials testing the same drug.
- NCT07389746 — Preoperative Physical Exercise, Nutritional Support, and Psychological Intervention (Multimodal Prehabilitation) to Stre · NA · not yet recruiting
- NCT07465159 — Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement · NA · recruiting
- NCT06069297 — Prehabilitation in Pancreatic Surgery · NA · recruiting
- NCT04461301 — Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplinary Trial · NA · recruiting
- NCT05034341 — Does Prehabilitation Improve Outcomes in Patients Undergoing Complex Spine Fusion Surgery? · NA · terminated
Other recruiting trials for Hematopoietic Stem Cell Transplantation (HSCT)
Currently open trials in the same condition.
- NCT07061444 — Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients · NA · recruiting
- NCT07205523 — High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT) · recruiting
- NCT04691622 — Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts · Phase 1 · recruiting
Other Hospital del Salvador trials
Trials by the same sponsor.
- NCT02590978 — Early Cholecystectomy in Patients With Mild Gallstone Acute Pancreatitis · NA · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07255521 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital del Salvador
- Last refreshed: 15 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07255521.
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