Last reviewed · How we verify
NCT07252622: PLATO
Progesterone Levels and Frozen Embryo Transfer Outcomes
trial testing Blood draw in IVF in 659 participants. Not yet recruiting.
1 November 2028
Quick facts
| Lead sponsor | Shady Grove Fertility Reproductive Science Center |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 659 |
| Start date | 1 December 2025 |
| Primary completion | 1 November 2028 |
| Estimated completion | 1 November 2028 |
Drugs / interventions tested
- Blood draw — full drug profile →
Conditions studied
- IVF — all drugs for IVF →
Sponsor
Shady Grove Fertility Reproductive Science Center — full company profile →
Who can join
Adults 18 to 50, female only, with IVF. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Frozen embryo transfers (FET) now represent the majority of all embryo transfer cycles, and upwards of 60% live births in United States are now attributable to frozen embryo transfers (1). Exogenous progesterone for endometrial decidualization and luteal phase support is thought to be critical to both optimizing endometrial receptivity for implantation as well as sustaining early pregnancy prior to reliable secretory activity of the early placenta. The purpose of this study is to: 1. Determine the prevalence of low serum progesterone levels (less than 10 ng/ml) among patients undergoing a programmed embryo transfer cycle on the day of frozen embryo transfer. 2. Determine if serum progesterone \< 10 ng/ml on the day of frozen embryo transfer is associated with poorer FET outcomes: ongoing pregnancy (primary outcome), live birth, biochemical pregnancy, and clinical pregnancy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07252622
- Europe PMC full search
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- ESMO Meeting Library
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Other Shady Grove Fertility Reproductive Science Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07252622 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shady Grove Fertility Reproductive Science Center
- Last refreshed: 28 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07252622.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing