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NCT07247721: TENS vs PENS
Transcutaneous vs Percutaneous Electrical Stimulation of the Radial Nerve
NA trial testing Transcutaneous Electrical Nerve Stimulation (TENS) in Pain Modulation in 120 participants. Participants enrolled and being followed up; not accepting new ones.
15 March 2026
Quick facts
| Lead sponsor | University of Castilla-La Mancha |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 15 January 2026 |
| Primary completion | 15 March 2026 |
| Estimated completion | 15 April 2026 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Percutaneous Electrical Nerve Stimulation (PENS)
- Sham Transcutaneous Electrical Nerve Stimulation
- Sham Percutaneous Electrical Nerve Stimulation
Conditions studied
- Pain Modulation — all drugs for Pain Modulation →
- Sensorimotor Function — all drugs for Sensorimotor Function →
- Nerve Stimulation — all drugs for Nerve Stimulation →
Sponsor
University of Castilla-La Mancha
Who can join
Adults 18 to 60, any sex, with Pain Modulation or Sensorimotor Function. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to compare the effects of two types of electrical nerve stimulation techniques-Transcutaneous Electrical Nerve Stimulation (TENS) and Percutaneous Electrical Nerve Stimulation (PENS)-on the sensory and motor components of the radial nerve in healthy volunteers. Transcutaneous Electrical Nerve Stimulation (TENS) is a non-invasive, low-cost, and widely used electrotherapy technique that applies electrical currents through surface electrodes on the skin to relieve pain. Percutaneous Electrical Nerve Stimulation (PENS) is a minimally invasive technique that delivers the electrical current through fine needles inserted near a peripheral nerve, potentially producing stronger physiological effects. In this randomized, double-blind controlled clinical trial, 120 healthy participants aged 18-60 years will be randomly assigned to one of four groups: Transcutaneous Electrical Nerve Stimulation (TENS) Percutaneous Electrical Nerve Stimulation (PENS) Sham Transcutaneous Electrical Nerve Stimulation (TENS) (placebo) Sham Percutaneous Electrical Nerve Stimulation (placebo) Each participant will receive one 20-minute stimulation session. Outcomes will include: Pressure pain threshold (PPT) (measured with an algometer), Thermal pain threshold (measured with a thermode), Maximal Isometric wrist extensor strength (measured with a hand-held dynamometer). The goal is to determine whether Percutaneous Electrical Nerve Stimulation (PENS) produces greater changes in sensory and motor parameters than Transcutaneous Electrical Nerve Stimulation (TENS) and to evaluate differences compared to placebo. This research will improve understanding of the physiological effects of these commonly used electrotherapy modalities and support evidence-based decision-making in clinical practice.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07247721
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT07319754 — TENS for Pain and Sleep After Hernia Surgery · NA · not yet recruiting
- NCT07307703 — TENS for Anxiety, Pain, and Satisfaction After Laparoscopic Cholecystectomy · NA · recruiting
Other University of Castilla-La Mancha trials
Trials by the same sponsor.
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- NCT07419035 — Bipolar Radiofrequency for Genitourinary Syndrome of Menopause · NA · not yet recruiting
- NCT07452172 — Lumbar and Gluteal Motor Control in Chronic Low Back Pain · NA · not yet recruiting
- NCT07041944 — HEMImprove 1.0 in Children and Adolescents With Unilateral Cerebral Palsy · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07247721 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Castilla-La Mancha
- Last refreshed: 27 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07247721.
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