NCT07243210 is a NA clinical trial of Cold Saline Irrigation in Third Molar Surgery, sponsored by University of Medicine and Pharmacy at Ho Chi Minh City.

Who is sponsoring NCT07243210?

NCT07243210 is sponsored by University of Medicine and Pharmacy at Ho Chi Minh City.

What drugs are being tested in NCT07243210?

Interventions in NCT07243210: Cold Saline Irrigation, Room-Temperature Saline Irrigation (Control).

What condition does NCT07243210 study?

NCT07243210 studies Third Molar Surgery, Postoperative Complications, C-REACTIVE PROTEIN.

Is NCT07243210 still recruiting?

NCT07243210 is currently completed. Last updated 25 November 2025.

Last reviewed 2025-11-25 · How we verify

NCT07243210

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Irrigation Solution Temperature on Clinical Outcomes and Salivary CRP After Impacted Mandibular Third Molar Surgery

Completed NA Last updated 25 November 2025

What this trial tests

NA trial testing Cold Saline Irrigation in Third Molar Surgery in 14 participants. Completed in 31 July 2025.

Timeline

1 September 2024

Primary endpoint
31 July 2025

31 July 2025

Quick facts

Lead sponsor	University of Medicine and Pharmacy at Ho Chi Minh City
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	14
Start date	1 September 2024
Primary completion	31 July 2025
Estimated completion	31 July 2025
Sites	1 location across Vietnam

Drugs / interventions tested

Cold Saline Irrigation
Room-Temperature Saline Irrigation (Control)

Conditions studied

Third Molar Surgery — all drugs for Third Molar Surgery →
Postoperative Complications — all drugs for Postoperative Complications →
C-REACTIVE PROTEIN — all drugs for C-REACTIVE PROTEIN →

Sponsor

University of Medicine and Pharmacy at Ho Chi Minh City

Who can join

18 and older, any sex, with Third Molar Surgery or Postoperative Complications. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Surgical extraction of impacted mandibular third molars often requires bone removal using rotary instruments, in which friction between the bur and bone generates heat. Excessive temperature rise may lead to local bone necrosis, delayed healing, and increased postoperative complications. Continuous irrigation with saline solution is routinely performed to reduce heat generation, and cold saline irrigation (0-4℃) has been shown to provide better thermal control than room-temperature saline. This study aims to evaluate the effect of cold saline irrigation compared with room-temperature saline irrigation on postoperative outcomes following impacted mandibular third molar surgery. The assessed parameters include pain, swelling, trismus, and salivary C-reactive protein (CRP) levels as a biomarker of inflammation. Salivary CRP serves as a minimally invasive marker that reflects the systemic inflammatory response after surgery. This randomized controlled trial will be conducted at the University of Medicine and Pharmacy at Ho Chi Minh City. Eligible patients with bilateral impacted mandibular third molars will be enrolled. Each patient will undergo extraction of one tooth with cold saline irrigation (0-4℃) and the contralateral tooth with room-temperature saline irrigation. Postoperative outcomes will include pain intensity (VAS) on days 1, 2, and 7; facial swelling on days 1, 2, and 7; trismus on days 1, 2, and 7; and salivary CRP levels at baseline and postoperative day 2. The findings are expected to clarify the role of irrigation solution temperature in both subjective clinical outcomes and objective inflammatory markers, thereby providing evidence to optimize clinical protocols and reduce postoperative morbidity in third molar surgery.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Third Molar Surgery

Currently open trials in the same condition.

NCT07498361 — Comparative Analysis of fast-and Slow-absorbable Poly(Lactose-co-glycolide) Sutures in Oral Surgery: a Randomized Contro · NA · recruiting

Other University of Medicine and Pharmacy at Ho Chi Minh City trials

Trials by the same sponsor.

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NCT07487181 — A Survey of Traditional Medicine Pattern Identification in Patients With Erectile Dysfunction · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07243210 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Medicine and Pharmacy at Ho Chi Minh City
Last refreshed: 25 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07243210.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing