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NCT07241130
Using End-Tidal CO₂ to Help Diagnose and Monitor Pulmonary Embolism
trial testing thrombolytic therapy in Pulmonary Embolism Acute in 120 participants. Completed in 30 July 2025.
30 July 2025
Quick facts
| Lead sponsor | Ataturk University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 120 |
| Start date | 1 February 2025 |
| Primary completion | 30 July 2025 |
| Estimated completion | 30 July 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- thrombolytic therapy — full drug profile →
Conditions studied
- Pulmonary Embolism Acute — all drugs for Pulmonary Embolism Acute →
Sponsor
Ataturk University
Who can join
Adults 18 to 80, any sex, with Pulmonary Embolism Acute. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pulmonary embolism (PE) can reduce blood flow in the lungs and impair gas exchange, leading to lower end-tidal carbon dioxide (EtCO₂) levels. This prospective observational study aims to evaluate whether EtCO₂ can help identify high-risk and intermediate-high-risk patients and monitor early treatment response, especially during thrombolytic therapy. A total of 120 participants were included: high-risk PE, intermediate-high-risk PE patients who received thrombolysis, intermediate-high-risk PE patients treated only with anticoagulation, and healthy controls. The study measured EtCO₂ along with oxygen saturation, heart rate, respiratory rate, perfusion index, and radiological obstruction scores. By comparing these parameters at diagnosis and during the first 24 hours, the study seeks to determine whether EtCO₂ can serve as a simple, noninvasive marker of disease severity and early hemodynamic improvement in patients with acute PE.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07241130
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
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- NCT07029841 — Cohort Study on Treatment Comes of Catheter-based Therapy in Patients With Acute Pulmonary Embolism in Hong Kong · recruiting
- NCT06348459 — Registry of Catheter Intervention in Pulmonary Embolism · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07241130 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ataturk University
- Last refreshed: 22 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07241130.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing