NCT07239557

Optimal Interval for Periodic Alveolar Recruitment Maneuvers Achieving 90% Lung Re-expansion During Intraoperative Ventilation

Not yet recruiting NA Last updated 20 November 2025

What this trial tests

NA trial testing Different interval of PARM in Major Abdominal Surgery in 52 participants. Not yet recruiting.

Timeline

1 January 2026

Primary endpoint
31 December 2026

31 December 2026

Quick facts

Lead sponsor	Sixth Affiliated Hospital, Sun Yat-sen University
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	na
Design	sequential
Masking	none
Primary purpose	prevention
Enrollment	52
Start date	1 January 2026
Primary completion	31 December 2026
Estimated completion	31 December 2026

Drugs / interventions tested

• Different interval of PARM

Conditions studied

• Major Abdominal Surgery — all drugs for Major Abdominal Surgery →
• Atelectasis — all drugs for Atelectasis →
• Lung-protective Ventilation — all drugs for Lung-protective Ventilation →
• Lung Ultrasound Score — all drugs for Lung Ultrasound Score →

Sponsor

Sixth Affiliated Hospital, Sun Yat-sen University

Who can join

Adults 65 to 80, any sex, with Major Abdominal Surgery or Atelectasis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to determine the optimal interval for periodic alveolar recruitment maneuvers (PARM) that can achieve effective lung re-expansion in 90% of patients undergoing intraoperative mechanical ventilation during abdominal laparoscopic surgery in the low Trendelenburg position. Identifying the most effective frequency of PARM is crucial for establishing lung-protective ventilation strategies, with the ultimate goal of reducing intraoperative atelectasis, decreasing postoperative pulmonary complications, and accelerating recovery.

Patients are randomized using a biased-coin sequential design. PARM is initially applied every 0.5 hours, and the effectiveness of lung re-expansion is evaluated before the end of surgery. The primary outcome is the effectiveness of recruitment, assessed by a combination of lung ultrasound scores and shunt fraction. Secondary outcomes include mechanical power at the end of surgery, time-weighted average mechanical power during ventilation, postoperative P/F ratio, dead space fraction, air test results, intraoperative adverse events, incidence of respiratory failure in the PACU and postoperative period, and postoperative length of stay.

This trial is expected to provide robust evidence for defining the optimal RM interval in protective ventilation protocols for patients undergoing laparoscopic abdominal surgery, thereby contributing to improved perioperative respiratory outcomes.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.