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NCT07235865: CarMA
Non-Invasive Diagnosis and Monitoring of Cardiac Masses by Liquid Biopsy
trial testing NGS-guided regimen: Regimen A in Cardiac Masses in 26 participants. Currently enrolling.
1 January 2025
Quick facts
| Lead sponsor | Niguarda Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 26 |
| Start date | 25 July 2024 |
| Primary completion | 1 January 2025 |
| Estimated completion | 25 December 2026 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- NGS-guided regimen: Regimen A — full drug profile →
Conditions studied
- Cardiac Masses — all drugs for Cardiac Masses →
Sponsor
Niguarda Hospital
Who can join
12 and older, any sex, with Cardiac Masses. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a nonprofit, observational, prospective and retrospective,multicenter study in a population of young and adult patients ≥12 years with a diagnosis of a cardiac mass. The study will include both patients with masses of unknown pathological diagnosis and patients with a known histology of benign or malignant tumors. We predict a case-control allocation ratio of 1:1 between cardiac malignant tumors and benign lesions. Peripheral blood will be collected at participating centers during routine venipuncture,processed and then shipped for liquid biopsy ctDNA NGS analyses. If available, in malignant cases, matched tumor tissue samples collected as per clinical practice solid biopsies or surgery will be used for analyses. Longitudinal tracking through serial blood draws could be performed in selected cases of patients with cardiac malignancies who receive cancer treatment
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07235865
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Niguarda Hospital trials
Trials by the same sponsor.
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- NCT07432347 — Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07235865 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Niguarda Hospital
- Last refreshed: 15 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07235865.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing