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NCT07226635: DDI
Pharmacokinetic Interaction Trial of Clofutriben With Midazolam and Prednisolone
Phase 1 trial testing midazolam in Healthy Participants in 16 participants. Completed in 16 December 2025.
16 December 2025
Quick facts
| Lead sponsor | Sparrow Pharmaceuticals |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | single group |
| Masking | none |
| Primary purpose | other |
| Enrollment | 16 |
| Start date | 3 October 2025 |
| Primary completion | 16 December 2025 |
| Estimated completion | 16 December 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- midazolam (midazolam) — full drug profile →
- clofutriben once daily for 16 days — full drug profile →
- 2 single oral doses of prednisolone — full drug profile →
Conditions studied
- Healthy Participants — all drugs for Healthy Participants →
Sponsor
Sparrow Pharmaceuticals — full company profile →
Who can join
Adults 18 to 75, any sex, with Healthy Participants. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Drug: 2 single oral doses of midazolam, 2 single oral doses of prednisolone , and clofutriben once daily for 16 days.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07226635
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Currently open trials in the same condition.
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Other Sparrow Pharmaceuticals trials
Trials by the same sponsor.
- NCT07227922 — Clofutriben Pharmacokinetics in Patients With Impaired Renal Function · Phase 1 · recruiting
- NCT07296484 — Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D) · Phase 2 · recruiting
- NCT05436639 — SPI-62 as a Treatment for Hypercortisolism Related to a Benign Adrenal Tumor · Phase 2 · completed
- NCT05307328 — SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome · Phase 2 · completed
- NCT05436652 — A Trial of Prednisolone in Combination With SPI-62 or Placebo in Subjects With Polymyalgia Rheumatica (PMR) · Phase 2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07226635 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sparrow Pharmaceuticals
- Last refreshed: 23 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07226635.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing