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NCT07225764
CaOx Stone Prevention
Phase 4 trial testing Chlorthalidone in Kidney Stones in 80 participants. Currently enrolling.
1 June 2027
Quick facts
| Lead sponsor | Icahn School of Medicine at Mount Sinai |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 80 |
| Start date | 23 October 2025 |
| Primary completion | 1 June 2027 |
| Estimated completion | 30 June 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Chlorthalidone — full drug profile →
- Low oxalate diet
Conditions studied
- Kidney Stones — all drugs for Kidney Stones →
Sponsor
Icahn School of Medicine at Mount Sinai
Who can join
18 and older, any sex, with Kidney Stones. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This single-center randomized controlled trial at Mount Sinai West will enroll 80 patients undergoing percutaneous nephrolithotomy for calcium oxalate stones. Participants will be randomized to receive either empiric therapy or selective therapy guided by 24-hour urine evaluation. The primary outcome is change in calcium oxalate supersaturation at 4 weeks, aiming to determine whether empiric therapy can provide outcomes comparable to selective therapy while simplifying access to prevention.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07225764
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Chlorthalidone
Trials testing the same drug.
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- NCT05915286 — Diuretic Use in Hemodialysis Patients With Residual Renal Function · Phase 4 · suspended
- NCT05275907 — Mechanism of Hypertension Treatments in Liver Transplant Recipients (BLOCK LTR-HTN) · Phase 4 · withdrawn
- NCT05222191 — Spironolactone in CKD Enabled by Chlorthalidone: PILOT · Phase 2 · unknown
- NCT04757532 — Study of Exposure to Substances Prohibited by the World Anti-Doping Agency in Healthy Volunteers. · Phase 1 · completed
Other recruiting trials for Kidney Stones
Currently open trials in the same condition.
- NCT07492147 — Effect of Negative Pressure Suction on Fluid Absorption and Infection in Flexible Ureteroscopy · recruiting
- NCT07332286 — FANS-Assisted Mini-PCNL for Complex Renal Stones · NA · active not recruiting
- NCT07055282 — SGLT2i in Kidney Stones · EARLY_PHASE1 · recruiting
- NCT07159035 — Flexible Ureteroscopy With a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithot · NA · recruiting
- NCT07174479 — Eye Gaze Guidance Evaluation in Phantoms · NA · recruiting
Other Icahn School of Medicine at Mount Sinai trials
Trials by the same sponsor.
- NCT07094308 — The LIFT-ECHO Last Mile Project · NA · not yet recruiting
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- NCT07194187 — High Intensity Focused Ultrasound (HIFU) Ablation for Treatment of Prostate Tissue in Bladder Outlet Obstruction · NA · not yet recruiting
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- NCT07487948 — Safety and Biomarker Responses of Delgocitinib (JAK1,2,3/TYK2 Inhibitor) in Central Centrifugal Cicatricial Alopecia and · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07225764 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Icahn School of Medicine at Mount Sinai
- Last refreshed: 10 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07225764.
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