NCT07221617 (OMICS) is a Phase 4 clinical trial of Methadone, oral in Pain, Postoperative, sponsored by Mayo Clinic.

Who is sponsoring NCT07221617?

NCT07221617 is sponsored by Mayo Clinic.

What drugs are being tested in NCT07221617?

Interventions in NCT07221617: Methadone, oral, Methadone, intravenously.

What condition does NCT07221617 study?

NCT07221617 studies Pain, Postoperative, Anesthesia, Cardiac Surgery.

Is NCT07221617 still recruiting?

NCT07221617 is currently recruiting now. Last updated 13 January 2026.

Last reviewed 2026-01-13 · How we verify

NCT07221617: OMICS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Oral Methadone In Cardiac Surgery

Recruiting now Phase 4 Last updated 13 January 2026

What this trial tests

Phase 4 trial testing Methadone, oral in Pain, Postoperative in 100 participants. Currently enrolling.

Timeline

13 January 2026

Primary endpoint
30 June 2026

1 August 2026

Quick facts

Lead sponsor	Mayo Clinic
Phase	Phase 4
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	100
Start date	13 January 2026
Primary completion	30 June 2026
Estimated completion	1 August 2026
Sites	1 location across United States

Drugs / interventions tested

Methadone, oral — full drug profile →
Methadone, intravenously — full drug profile →

Conditions studied

Pain, Postoperative — all drugs for Pain, Postoperative →
Anesthesia — all drugs for Anesthesia →
Cardiac Surgery — all drugs for Cardiac Surgery →

Sponsor

Mayo Clinic

Who can join

18 and older, any sex, with Pain, Postoperative or Anesthesia. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Amount of opioid medication used 72 hours post-extubation
Time frame: From hospital admission for surgery to 72 hours after the patient is extubated postoperatively
Opioid medication used at 72 hours post-extubation will be reported in morphine milligram equivalents

Sponsor's own description

The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Pain, Postoperative

Currently open trials in the same condition.

NCT07512141 — Single Versus Double Drains in the Axillary and Pectoral Regions After Modified Radical Mastectomy · NA · recruiting
NCT07354581 — Erector Spinae Plane Block vs Quadro-Iliac Plane Block After Lumbar Instrumentation Surgery · NA · recruiting
NCT07239817 — PENG Block + LIA For Endoprosthesis Surgery With Anterior Approach · NA · recruiting
NCT06740214 — Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty · Phase 3 · recruiting
NCT07057557 — Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites · NA · recruiting

Other Mayo Clinic trials

Trials by the same sponsor.

NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07221617 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 13 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07221617.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing